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Int. J. Mol. Sci. 2018, 19(2), 632; https://doi.org/10.3390/ijms19020632

Alternative mRNA Splicing in the Pathogenesis of Obesity

1
Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China
2
The State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
3
School of Medical and Health Sciences, Tung Wah College, Hong Kong, China
*
Author to whom correspondence should be addressed.
Received: 5 January 2018 / Revised: 21 February 2018 / Accepted: 21 February 2018 / Published: 23 February 2018
(This article belongs to the Special Issue Pre-mRNA Splicing 2017)
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Abstract

Alternative mRNA splicing is an important mechanism in expansion of proteome diversity by production of multiple protein isoforms. However, emerging evidence indicates that only a limited number of annotated protein isoforms by alternative splicing are detected, and the coding sequence of alternative splice variants usually is only slightly different from that of the canonical sequence. Nevertheless, mis-splicing is associated with a large array of human diseases. Previous reviews mainly focused on hereditary and somatic mutations in cis-acting RNA sequence elements and trans-acting splicing factors. The importance of environmental perturbations contributed to mis-splicing is not assessed. As significant changes in exon skipping and splicing factors expression levels are observed with diet-induced obesity, this review focuses on several well-known alternatively spliced metabolic factors and discusses recent advances in the regulation of the expressions of splice variants under the pathophysiological conditions of obesity. The potential of targeting the alternative mRNA mis-splicing for obesity-associated diseases therapies will also be discussed. View Full-Text
Keywords: alternative mRNA splicing; obesity-related diseases; splice variants; splicing factors; insulin receptor; leptin receptor; lipin-1; nuclear receptor corepressor; LMNA; RNA binding protein; Fox-1 Homolog 2; NOVA splicing factors alternative mRNA splicing; obesity-related diseases; splice variants; splicing factors; insulin receptor; leptin receptor; lipin-1; nuclear receptor corepressor; LMNA; RNA binding protein; Fox-1 Homolog 2; NOVA splicing factors
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Wong, C.-M.; Xu, L.; Yau, M.Y.-C. Alternative mRNA Splicing in the Pathogenesis of Obesity. Int. J. Mol. Sci. 2018, 19, 632.

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