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Int. J. Mol. Sci. 2018, 19(2), 559; https://doi.org/10.3390/ijms19020559

New Insights into the Tumor Microenvironment Utilizing Protein Array Technology

1
RayBiotech, Inc., Guangzhou, 79 Ruihe Road, Huangpu District, Guangzhou 510600, China
2
South China Biochip Research Center, 79 Ruihe Road, Huangpu District, Guangzhou 510600, China
3
RayBiotech, Inc., 3607 Parkway Lane, Norcross, GA 30092, USA
*
Author to whom correspondence should be addressed.
Received: 30 November 2017 / Revised: 22 December 2017 / Accepted: 6 February 2018 / Published: 13 February 2018
(This article belongs to the Special Issue Tumor Microenvironment)
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Abstract

The tumor microenvironment (TME) is a considerably heterogeneous niche, which is created by tumor cells, the surrounding tumor stroma, blood vessels, infiltrating immune cells, and a variety of associated stromal cells. Intercellular communication within this niche is driven by soluble proteins synthesized by local tumor and stromal cells and include chemokines, growth factors, interferons, interleukins, and angiogenic factors. The interaction of tumor cells with their microenvironment is essential for tumorigenesis, tumor progression, growth, and metastasis, and resistance to drug therapy. Protein arrays enable the parallel detection of hundreds of proteins in a small amount of biological sample. Recent data have demonstrated that the application of protein arrays may yield valuable information regarding the structure and functional mechanisms of the TME. In this review, we will discuss protein array technologies and their applications in TME analysis to discern pathways involved in promoting the tumorigenic phenotype. View Full-Text
Keywords: protein array; antibody array; microarray; tumor microenvironment; cancer stem cell; cancer protein array; antibody array; microarray; tumor microenvironment; cancer stem cell; cancer
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Huang, W.; Luo, S.; Burgess, R.; Yi, Y.-H.; Huang, G.F.; Huang, R.-P. New Insights into the Tumor Microenvironment Utilizing Protein Array Technology. Int. J. Mol. Sci. 2018, 19, 559.

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