The Low-Renin Hypertension Phenotype: Genetics and the Role of the Mineralocorticoid Receptor
AbstractA substantial proportion of patients with hypertension have a low or suppressed renin. This phenotype of low-renin hypertension (LRH) may be the manifestation of inherited genetic syndromes, acquired somatic mutations, or environmental exposures. Activation of the mineralocorticoid receptor is a common final mechanism for the development of LRH. Classically, the individual causes of LRH have been considered to be rare diseases; however, recent advances suggest that there are milder and “non-classical” variants of many LRH-inducing conditions. In this regard, our understanding of the underlying genetics and mechanisms accounting for LRH, and therefore, potentially the pathogenesis of a large subset of essential hypertension, is evolving. This review will discuss the potential causes of LRH, with a focus on implicated genetic mechanisms, the expanding recognition of non-classical variants of conditions that induce LRH, and the role of the mineralocorticoid receptor in determining this phenotype. View Full-Text
Share & Cite This Article
Baudrand, R.; Vaidya, A. The Low-Renin Hypertension Phenotype: Genetics and the Role of the Mineralocorticoid Receptor. Int. J. Mol. Sci. 2018, 19, 546.
Baudrand R, Vaidya A. The Low-Renin Hypertension Phenotype: Genetics and the Role of the Mineralocorticoid Receptor. International Journal of Molecular Sciences. 2018; 19(2):546.Chicago/Turabian Style
Baudrand, Rene; Vaidya, Anand. 2018. "The Low-Renin Hypertension Phenotype: Genetics and the Role of the Mineralocorticoid Receptor." Int. J. Mol. Sci. 19, no. 2: 546.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.