Integrins in T Cell Physiology
AbstractFrom the thymus to the peripheral lymph nodes, integrin-mediated interactions with neighbor cells and the extracellular matrix tune T cell behavior by organizing cytoskeletal remodeling and modulating receptor signaling. LFA-1 (αLβ2 integrin) and VLA-4 (α4β1 integrin) play a key role throughout the T cell lifecycle from thymocyte differentiation to lymphocyte extravasation and finally play a fundamental role in organizing immune synapse, providing an essential costimulatory signal for the T cell receptor. Apart from tuning T cell signaling, integrins also contribute to homing to specific target organs as exemplified by the importance of α4β7 in maintaining the gut immune system. However, apart from those well-characterized examples, the physiological significance of the other integrin dimers expressed by T cells is far less understood. Thus, integrin-mediated cell-to-cell and cell-to-matrix interactions during the T cell lifespan still represent an open field of research. View Full-Text
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Bertoni, A.; Alabiso, O.; Galetto, A.S.; Baldanzi, G. Integrins in T Cell Physiology. Int. J. Mol. Sci. 2018, 19, 485.
Bertoni A, Alabiso O, Galetto AS, Baldanzi G. Integrins in T Cell Physiology. International Journal of Molecular Sciences. 2018; 19(2):485.Chicago/Turabian Style
Bertoni, Alessandra; Alabiso, Oscar; Galetto, Alessandra S.; Baldanzi, Gianluca. 2018. "Integrins in T Cell Physiology." Int. J. Mol. Sci. 19, no. 2: 485.
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