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Int. J. Mol. Sci. 2018, 19(2), 436; doi:10.3390/ijms19020436

When Immune Cells Turn Bad—Tumor-Associated Microglia/Macrophages in Glioma

Division of Experimental Neurosurgery, Department of Neurosurgery, University Hospital Heidelberg, INF400, 69120 Heidelberg, Germany
Author to whom correspondence should be addressed.
Received: 8 December 2017 / Revised: 29 December 2017 / Accepted: 29 January 2018 / Published: 1 February 2018
(This article belongs to the Special Issue Glioma Cell Invasion)
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As a substantial part of the brain tumor microenvironment (TME), glioma-associated microglia/macrophages (GAMs) have an emerging role in tumor progression and in controlling anti-tumor immune responses. We review challenges and improvements of cell models and highlight the contribution of this highly plastic cell population to an immunosuppressive TME, besides their well-known functional role regarding glioma cell invasion and angiogenesis. Finally, we summarize first therapeutic interventions to target GAMs and their effect on the immunobiology of gliomas, focusing on their interaction with T cells. View Full-Text
Keywords: microglia; glioma-associated microglia/macrophages; GAMs; glioma; glioblastoma; GBM; tumor microenvironment; TME microglia; glioma-associated microglia/macrophages; GAMs; glioma; glioblastoma; GBM; tumor microenvironment; TME

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Roesch, S.; Rapp, C.; Dettling, S.; Herold-Mende, C. When Immune Cells Turn Bad—Tumor-Associated Microglia/Macrophages in Glioma. Int. J. Mol. Sci. 2018, 19, 436.

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