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Int. J. Mol. Sci. 2018, 19(2), 343; https://doi.org/10.3390/ijms19020343

Disrupting the Btk Pathway Suppresses COPD-Like Lung Alterations in Atherosclerosis Prone ApoE−/− Mice Following Regular Exposure to Cigarette Smoke

1
Department of Cellular and Molecular Biology, University of Texas Health Science Center, Tyler, TX 75708, USA
2
Laboratory of Gastroimmunology, Department of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Lodz, 90-237 Lodz, Poland
*
Author to whom correspondence should be addressed.
Received: 15 November 2017 / Revised: 19 January 2018 / Accepted: 21 January 2018 / Published: 24 January 2018
(This article belongs to the Special Issue Lung Diseases: Chronic Respiratory Infections)
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Abstract

Chronic obstructive pulmonary disease (COPD) is associated with severe chronic inflammation that promotes irreversible tissue destruction. Moreover, the most broadly accepted cause of COPD is exposure to cigarette smoke. There is no effective cure and significantly, the mechanism behind the development and progression of this disease remains unknown. Our laboratory has demonstrated that Bruton’s tyrosine kinase (Btk) is a critical regulator of pro-inflammatory processes in the lungs and that Btk controls expression of matrix metalloproteinase-9 (MMP-9) in the alveolar compartment. For this study apolipoprotein E null (ApoE−/−) mice were exposed to SHS to facilitate study in a COPD/atherosclerosis comorbidity model. We applied two types of treatments, animals received either a pharmacological inhibitor of Btk or MMP-9 specific siRNA to minimize MMP-9 expression in endothelial cells or neutrophils. We have shown that these treatments had a protective effect in the lung. We have noted a decrease in alveolar changes related to SHS induced inflammation in treated animals. In summary, we are presenting a novel concept in the field of COPD, i.e., that Btk may be a new drug target for this disease. Moreover, cell specific targeting of MMP-9 may also benefit patients affected by this disease. View Full-Text
Keywords: chronic lung inflammation; emphysema; second hand smoke; Bruton’s tyrosine kinase; matrix metalloproteinase-9 chronic lung inflammation; emphysema; second hand smoke; Bruton’s tyrosine kinase; matrix metalloproteinase-9
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Florence, J.M.; Krupa, A.; Booshehri, L.M.; Gajewski, A.L.; Kurdowska, A.K. Disrupting the Btk Pathway Suppresses COPD-Like Lung Alterations in Atherosclerosis Prone ApoE−/− Mice Following Regular Exposure to Cigarette Smoke. Int. J. Mol. Sci. 2018, 19, 343.

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