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Int. J. Mol. Sci. 2018, 19(1), 80; doi:10.3390/ijms19010080

Role of Stem Cells in Pathophysiology and Therapy of Spondyloarthropathies—New Therapeutic Possibilities?

1
Department of Rheumatology, Municipal Hospital in Olsztyn, 10-900 Olsztyn, Poland
2
Department of Pathophysiology, Faculty of Medicine, University of Warmia and Mazury, 10-900 Olsztyn, Poland
3
Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, Faculty of Medicine, University of Warmia and Mazury, 10-900 Olsztyn, Poland
4
Department of Forensic Medicine, Faculty of Medicine, University of Warmia and Mazury, 10-900 Olsztyn, Poland
5
Laboratory for Regenerative Medicine, Faculty of Medicine, University of Warmia and Mazury, 10-900 Olsztyn, Poland
6
Foundation for Nerve Cell Regeneration, University of Warmia and Mazury in Olsztyn, 10-900 Olsztyn, Poland
*
Authors to whom correspondence should be addressed.
Received: 26 November 2017 / Revised: 23 December 2017 / Accepted: 25 December 2017 / Published: 28 December 2017
(This article belongs to the Special Issue Research of Pathogenesis and Novel Therapeutics in Arthritis)
View Full-Text   |   Download PDF [950 KB, uploaded 28 December 2017]   |  

Abstract

Considerable progress has been made recently in understanding the complex pathogenesis and treatment of spondyloarthropathies (SpA). Currently, along with traditional disease modifying anti-rheumatic drugs (DMARDs), TNF-α, IL-12/23 and IL-17 are available for treatment of such diseases as ankylosing spondylitis (AS) and psoriatic arthritis (PsA). Although they adequately control inflammatory symptoms, they do not affect the abnormal bone formation processes associated with SpA. However, the traditional therapeutic approach does not cover the regenerative treatment of damaged tissues. In this regards, stem cells may offer a promising, safe and effective therapeutic option. The aim of this paper is to present the role of mesenchymal stromal cells (MSC) in pathogenesis of SpA and to highlight the opportunities for using stem cells in regenerative processes and in the treatment of inflammatory changes in articular structures. View Full-Text
Keywords: spondyloarthropathies; inflammation; mesenchymal stem cells spondyloarthropathies; inflammation; mesenchymal stem cells
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Krajewska-Włodarczyk, M.; Owczarczyk-Saczonek, A.; Placek, W.; Osowski, A.; Engelgardt, P.; Wojtkiewicz, J. Role of Stem Cells in Pathophysiology and Therapy of Spondyloarthropathies—New Therapeutic Possibilities? Int. J. Mol. Sci. 2018, 19, 80.

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