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Int. J. Mol. Sci. 2018, 19(1), 67; doi:10.3390/ijms19010067

Enantiomeric Effect of d-Amino Acid Substitution on the Mechanism of Action of α-Helical Membrane-Active Peptides

1,2
,
1,2
,
1,2,3
,
4,5
,
4,5
,
4,5,* and 1,2,3,*
1
Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, Changchun 130012, China
2
School of Life Sciences, Jilin University, Changchun 130012, China
3
National Engineering Laboratory for AIDS Vaccine, Jilin University, Changchun 130012, China
4
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, China
5
University of Chinese Academy of Sciences, Beijing 100049, China
*
Authors to whom correspondence should be addressed.
Received: 3 November 2017 / Revised: 12 December 2017 / Accepted: 23 December 2017 / Published: 27 December 2017
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [3686 KB, uploaded 27 December 2017]   |  

Abstract

V13K, a 26-residue peptide, has been shown to have strong antimicrobial activity, negligible hemolytic activity, and significant anticancer activity. In the present work, V13K was used as the framework to investigate the influence of helicity, as influenced by d-amino acid substitutions in the center of the peptide polar and non-polar faces of the amphipathic helix, on biological activity. The antibacterial and anticancer activities of the peptides were investigated. Atomic force microscopy and other biophysical methods were used to investigate the effect of peptide helicity on biological activity. The results showed the importance of suitable and rational modification of membrane-active peptides, based on helicity, in optimizing potential biological activity. View Full-Text
Keywords: atomic force microscopy; membrane-active peptide; helicity; hydrophobicity atomic force microscopy; membrane-active peptide; helicity; hydrophobicity
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Sun, S.; Zhao, G.; Huang, Y.; Cai, M.; Yan, Q.; Wang, H.; Chen, Y. Enantiomeric Effect of d-Amino Acid Substitution on the Mechanism of Action of α-Helical Membrane-Active Peptides. Int. J. Mol. Sci. 2018, 19, 67.

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