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Int. J. Mol. Sci. 2018, 19(1), 51; https://doi.org/10.3390/ijms19010051

Emerging Roles of TWIK-1 Heterodimerization in the Brain

1
School of Biosystem and Biomedical Science, College of Health Science, Korea University, Seoul 136-703, Korea
2
Korea Institute of Science and Technology (KIST), Center for Functional Connectomics, Seoul 02792, Korea
3
KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul 02447, Korea
*
Authors to whom correspondence should be addressed.
Received: 28 November 2017 / Revised: 20 December 2017 / Accepted: 22 December 2017 / Published: 24 December 2017
(This article belongs to the Special Issue Ion Transporters and Channels in Physiology and Pathophysiology)
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Abstract

Two-pore domain K+ (K2P) channels play essential roles in regulating resting membrane potential and cellular excitability. Although TWIK-1 (TWIK—tandem of pore domains in a weak inward rectifying K+ channel) was the first identified member of the K2P channel family, it is only in recent years that the physiological roles of TWIK-1 have been studied in depth. A series of reports suggest that TWIK-1 may underlie diverse functions, such as intrinsic excitability of neurons, astrocytic passive conductance, and astrocytic glutamate release, as a homodimer or heterodimer with other K2P isotypes. Here, we summarize expression patterns and newly identified functions of TWIK-1 in the brain. View Full-Text
Keywords: TWIK-1; K2P; astrocyte; brain; heterodimerization TWIK-1; K2P; astrocyte; brain; heterodimerization
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Cho, C.-H.; Hwang, E.M.; Park, J.-Y. Emerging Roles of TWIK-1 Heterodimerization in the Brain. Int. J. Mol. Sci. 2018, 19, 51.

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