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Int. J. Mol. Sci. 2018, 19(1), 159; https://doi.org/10.3390/ijms19010159

Effects of Acanthopanax senticosus on Brain Injury Induced by Simulated Spatial Radiation in Mouse Model Based on Pharmacokinetics and Comparative Proteomics

1
Institute of Extreme Environment Nutrition and Protection, Harbin Institute of Technology, Harbin 150001, China
2
National Local Joint Laboratory of Extreme Environmental Nutritional Molecule Synthesis Transformation and Separation, Harbin 150001, China
3
Biotechnologies of the Third Millennium, ITMO University, Saint-Petersburg 197101, Russia
4
China Astronaut Research and Training Centre, Beijing 100193, China
*
Authors to whom correspondence should be addressed.
Received: 25 October 2017 / Revised: 25 December 2017 / Accepted: 3 January 2018 / Published: 15 January 2018
(This article belongs to the Special Issue Nutraceuticals in Human Health and Disease)
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Abstract

The active compounds in Acanthopanax senticosus (AS) have different pharmacokinetic characteristics in mouse models. Cmax and AUC of Acanthopanax senticosus polysaccharides (ASPS) were significantly reduced in radiation-injured mice, suggesting that the blood flow of mouse was blocked or slowed, due to the pathological state of ischemia and hypoxia, which are caused by radiation. In contrast, the ability of various metabolizing enzymes to inactivate, capacity of biofilm transport decrease, and lessening of renal blood flow accounts for radiation, resulting in the accumulation of syringin and eleutheroside E in the irradiated mouse. Therefore, there were higher pharmacokinetic parameters—AUC, MRT, and t1/2 of the two compounds in radiation-injured mouse, when compared with normal mouse. In order to investigate the intrinsic mechanism of AS on radiation injury, AS extract’s protective effects on brain, the main part of mouse that suffered from radiation, were explored. The function of AS extract in repressing expression changes of radiation response proteins in prefrontal cortex (PFC) of mouse brain included tubulin protein family (α-, β-tubulin subunits), dihydropyrimidinase-related protein 2 (CRMP2), γ-actin, 14-3-3 protein family (14-3-3ζ, ε), heat shock protein 90β (HSP90β), and enolase 2. The results demonstrated the AS extract had positive effects on nerve cells’ structure, adhesion, locomotion, fission, and phagocytosis, through regulating various action pathways, such as Hippo, phagosome, PI3K/Akt (phosphatidylinositol 3 kinase/protein kinase B), Neurotrophin, Rap1 (Ras-related protein RAP-1A), gap junction glycolysis/gluconeogenesis, and HIF-1 (Hypoxia-inducible factor 1) signaling pathways to maintain normal mouse neurological activity. All of the results indicated that AS may be a promising alternative medicine for the treatment of radiation injury in mouse brain. It would be tested that whether the bioactive ingredients of AS could be effective through the blood–brain barrier in the future. View Full-Text
Keywords: Acanthopanax senticosus (AS); brain injury; pharmacokinetic; proteomics Acanthopanax senticosus (AS); brain injury; pharmacokinetic; proteomics
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Zhou, Y.; Cheng, C.; Baranenko, D.; Wang, J.; Li, Y.; Lu, W. Effects of Acanthopanax senticosus on Brain Injury Induced by Simulated Spatial Radiation in Mouse Model Based on Pharmacokinetics and Comparative Proteomics. Int. J. Mol. Sci. 2018, 19, 159.

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