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Int. J. Mol. Sci. 2017, 18(9), 1959; doi:10.3390/ijms18091959

Therapeutic Implications of Autophagy Inducers in Immunological Disorders, Infection, and Cancer

1,†
,
2,†
and
3,4,*
1
Division of Bioengineering, Incheon National University, Incheon 22012, Korea
2
Traditional Alcoholic Beverage Research Team, Korea Food Research Institute, Seongnam 13539, Korea
3
Advanced Institutes of Convergence Technology, Seoul National University, Suwon 16495, Korea
4
Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea
These authors contributed equally to this work
*
Author to whom correspondence should be addressed.
Received: 31 July 2017 / Revised: 10 September 2017 / Accepted: 11 September 2017 / Published: 12 September 2017
(This article belongs to the Special Issue Autophagy at the Intersection of the Immune System and Cancer)
View Full-Text   |   Download PDF [272 KB, uploaded 13 September 2017]

Abstract

Autophagy is an essential catabolic program that forms part of the stress response and enables cells to break down their own intracellular components within lysosomes for recycling. Accumulating evidence suggests that autophagy plays vital roles in determining pathological outcomes of immune responses and tumorigenesis. Autophagy regulates innate and adaptive immunity affecting the pathologies of infectious, inflammatory, and autoimmune diseases. In cancer, autophagy appears to play distinct roles depending on the context of the malignancy by either promoting or suppressing key determinants of cancer cell survival. This review covers recent developments in the understanding of autophagy and discusses potential therapeutic interventions that may alter the outcomes of certain diseases. View Full-Text
Keywords: autophagy; immunity; cancer; activators autophagy; immunity; cancer; activators
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Byun, S.; Lee, E.; Lee, K.W. Therapeutic Implications of Autophagy Inducers in Immunological Disorders, Infection, and Cancer. Int. J. Mol. Sci. 2017, 18, 1959.

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