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Int. J. Mol. Sci. 2017, 18(9), 1861; doi:10.3390/ijms18091861

The Emerging Role of GLP-1 Receptors in DNA Repair: Implications in Neurological Disorders

1
Institute for Translation Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, 123 Dapi Road, Kaohsiung 83301, Taiwan
2
Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, 123 Dapi Road, Kaohsiung 83301, Taiwan
3
College of Medicine, Chang Gung University, 259 Wenhua 1st Road, Taoyuan 33302, Taiwan
*
Author to whom correspondence should be addressed.
Received: 5 July 2017 / Revised: 19 August 2017 / Accepted: 23 August 2017 / Published: 26 August 2017
(This article belongs to the Special Issue DNA Injury and Repair Systems)
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Abstract

Glucagon-like peptide-1 (GLP-1) is originally found as a metabolic hormone (incretin) that is able to regulate blood-glucose levels via promoting synthesis and secretion of insulin. GLP-1 and many analogues are approved for treatment of type II diabetes. Accumulating results imply that GLP-1 performs multiple functions in various tissues and organs beyond regulation of blood-glucose. The neuroprotective function of GLP-1 has been extensively explored during the past two decades. Three of our previous studies have shown that apurinic/apyrimidinic endonuclease 1 (APE1) is the only protein of the base excision repair (BER) pathway able to be regulated by oxidative stress or exogenous stimulations in rat primary cortical neurons. In this article, we review the role of APE1 in neurodegenerative diseases and its relationship to neuroprotective mechanisms of the activated GLP-1 receptor (GLP-1R) in neurodegenerative disorders. The purpose of this article is to provide new insight, from the aspect of DNA damage and repair, for studying potential treatments in neurodegenerative diseases. View Full-Text
Keywords: neurodegenerative disorders; DNA damage and repair; apurinic/apyrimidinic endonuclease 1 (APE1); glucagon-like peptide 1 receptor (GLP-1R) neurodegenerative disorders; DNA damage and repair; apurinic/apyrimidinic endonuclease 1 (APE1); glucagon-like peptide 1 receptor (GLP-1R)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Yang, J.-L.; Chen, W.-Y.; Chen, S.-D. The Emerging Role of GLP-1 Receptors in DNA Repair: Implications in Neurological Disorders. Int. J. Mol. Sci. 2017, 18, 1861.

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