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Int. J. Mol. Sci. 2017, 18(9), 1858; doi:10.3390/ijms18091858

The Candida albicans Inhibitory Activity of the Extract from Papaya (Carica papaya L.) Seed Relates to Mitochondria Dysfunction

1,2
and
1,*
1
College of Food Science, Hainan University, Haikou 570228, China
2
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China
*
Author to whom correspondence should be addressed.
Received: 26 July 2017 / Revised: 16 August 2017 / Accepted: 18 August 2017 / Published: 25 August 2017
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Abstract

The inhibitory activity of the papaya seed extract (PSE) on Candida albicans (C. albicans) was determined by turbidimetry method. The inhibitory mechanisms were also evaluated from the prospective of reactive oxygen species (ROS) generation, mitochondrial membrane potential (MMP) decrease, and the activities of four complex enzymes in mitochondria respiratory chain. Results obtained from this study indicated that the PSE exhibited an effective inhibitory activity on C. albicans and induced significant accumulation of ROS and collapse of MMP. The Complex I and Complex III exhibited continues significant decrease in mitochondrial enzyme activity assays, but the Complex II and Complex IV activities were not positively correlated. Furthermore, the GC-MS analysis demonstrated that the PSE represents a rich and high-purity source of benzyl isothiocyanate (BITC), which indicated the BITC may be responsible for the mitochondrial dysfunction. View Full-Text
Keywords: papaya seed; C. albicans; benzyl isothiocyanate; mitochondria dysfunction; reactive oxygen species papaya seed; C. albicans; benzyl isothiocyanate; mitochondria dysfunction; reactive oxygen species
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Zhang, T.; Chen, W. The Candida albicans Inhibitory Activity of the Extract from Papaya (Carica papaya L.) Seed Relates to Mitochondria Dysfunction. Int. J. Mol. Sci. 2017, 18, 1858.

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