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Int. J. Mol. Sci. 2017, 18(9), 1850; doi:10.3390/ijms18091850

Importance of Endogenous Fibrinolysis in Platelet Thrombus Formation

1
Department of Cardiology, East and North Hertfordshire NHS Trust, Hertfordshire SG1 4AB, UK
2
Department of Postgraduate Medicine, University of Hertfordshire, Hertfordshire AL10 9AB, UK
3
National Heart & Lung Institute, Imperial College, London SW3 6LY, UK
*
Author to whom correspondence should be addressed.
Received: 7 July 2017 / Revised: 21 August 2017 / Accepted: 21 August 2017 / Published: 25 August 2017
(This article belongs to the Special Issue Mechanisms of Platelet Thrombus Formation)
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Abstract

The processes of thrombosis and coagulation are finely regulated by endogenous fibrinolysis maintaining healthy equilibrium. When the balance is altered in favour of platelet activation and/or coagulation, or if endogenous fibrinolysis becomes less efficient, pathological thrombosis can occur. Arterial thrombosis remains a major cause of morbidity and mortality in the world despite advances in medical therapies. The role endogenous fibrinolysis in the pathogenesis of arterial thrombosis has gained increasing attention in recent years as it presents novel ways to prevent and treat existing diseases. In this review article, we discuss the role of endogenous fibrinolysis in platelet thrombus formation, methods of measurement of fibrinolytic activity, its role in predicting cardiovascular diseases and clinical outcomes and future directions. View Full-Text
Keywords: endogenous; spontaneous; thrombolysis; fibrinolysis; thrombosis; platelets; cardiovascular endogenous; spontaneous; thrombolysis; fibrinolysis; thrombosis; platelets; cardiovascular
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Gue, Y.X.; Gorog, D.A. Importance of Endogenous Fibrinolysis in Platelet Thrombus Formation. Int. J. Mol. Sci. 2017, 18, 1850.

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