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Int. J. Mol. Sci. 2017, 18(9), 1478; doi:10.3390/ijms18091478

Human Leukocyte Antigen Class I and Class II Polymorphisms and Serum Cytokine Profiles in Cervical Cancer

1
Laboratory of Immunogenetics, Department of Basic Health Sciences, State University of Maringá (UEM), 87020-900 Maringá, PR, Brazil
2
Laboratory of Clinical Cytology, Department of Clinical Analysis and Biomedicine, State University of Maringá (UEM), 87020-900 Maringá, PR, Brazil
3
Post Graduate Program of Biosciences and Physiopathology, Clinical Analysis and Biomedicine Department, State University of Maringá (UEM), 87020-900 Maringá, PR, Brazil
4
Laboratory of Clinical and Toxicological Analysis, Department of Pathology, State University of Londrina (UEL), 86057-970 Londrina, PR, Brazil
*
Author to whom correspondence should be addressed.
Received: 4 April 2017 / Revised: 23 June 2017 / Accepted: 4 July 2017 / Published: 31 August 2017
(This article belongs to the Special Issue Major Histocompatibility Complex)
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Abstract

Only a small proportion of women who are exposed to infection with high-risk human papillomavirus (HR-HPV) progress to persistent infection and develop cervical cancer (CC). The immune response and genetic background of the host may affect the risk of progression from a HR-HPV infection to lesions and cancer. However, to our knowledge, no studies has been conducted to evaluate the relationship between variability of human leukocyte antigens (HLA) genes and serum cytokine expression in this pathology. In the current study, we examined the associations of HLA alleles and haplotypes including Class I (HLA-A, -B and -C) and II (HLA-DRB1, -DQA1 and -DQB1) with serum levels of cytokines interleukin (IL)-6, tumor necrosis factor-α (TNF-α), IL-10 and IL-17 as well as risks of HPV infections, lesions and CC among admixed Brazilian women. HLA polymorphisms were associated with an increased risk or protection from HPV, lesions and CC. Additionally, we demonstrated a potential association of a HLA class I haplotype (HLA-B*14-C*08) with higher IL-10 cytokine serum levels in cervical disease, suggesting an association between HLA class I and specific cytokines in cervical carcinogenesis. However, larger studies with detailed HPV types coupled with genetic data are needed to further evaluate the effects of HLA and CC by HPV genotype. View Full-Text
Keywords: genes, major histocompatibility complex class I; genes, major histocompatibility complex class II; serum cytokines; papillomavirus infections; uterine cervical dysplasia; uterine cervical neoplasms genes, major histocompatibility complex class I; genes, major histocompatibility complex class II; serum cytokines; papillomavirus infections; uterine cervical dysplasia; uterine cervical neoplasms
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Bahls, L.; Yamakawa, R.; Zanão, K.; Alfieri, D.; Flauzino, T.; Delongui, F.; de Abreu, A.; Souza, R.; Gimenes, F.; Reiche, E.; Borelli, S.; Consolaro, M. Human Leukocyte Antigen Class I and Class II Polymorphisms and Serum Cytokine Profiles in Cervical Cancer. Int. J. Mol. Sci. 2017, 18, 1478.

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