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Int. J. Mol. Sci. 2017, 18(8), 1717; doi:10.3390/ijms18081717

Respiratory Syncytial Virus: The Influence of Serotype and Genotype Variability on Clinical Course of Infection

1
Pediatrics and Neonatology Unit, Imola Hospital, 40026 Imola, Italy
2
Department of Pediatric Emergency, S. Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, Italy
*
Author to whom correspondence should be addressed.
Received: 29 June 2017 / Revised: 26 July 2017 / Accepted: 30 July 2017 / Published: 6 August 2017
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Abstract

Respiratory syncytial virus (RSV) belongs to the recently defined Pneumoviridae family, Orthopneumovirus genus. It is the leading cause of acute bronchiolitis and one of the most common causes of infant viral death worldwide, with infection typically occurring as recurrent seasonal epidemics. There are two major RSV subtypes, A and B, and multiple genotypes, which can coexist during RSV epidemic season every year and result in different disease severity. Recently, new RSV genomic sequences and analysis of RSV genotypes have provided important data for understanding RSV pathogenesis. Novel RSV strains do spread rapidly and widely, and a knowledge of viral strain-specific phenotypes may be important in order to include the more virulent strains in future therapeutical options and vaccine development. Here we summarize recent literature exploring genetic and molecular aspects related to RSV infection, their impact on the clinical course of the disease and their potential utility in the development of safe and effective preventive and therapeutic strategies. View Full-Text
Keywords: respiratory syncytial virus; genotype; children; lower respiratory tract infections; bronchiolitis; monoclonal antibodies; vaccines respiratory syncytial virus; genotype; children; lower respiratory tract infections; bronchiolitis; monoclonal antibodies; vaccines
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Vandini, S.; Biagi, C.; Lanari, M. Respiratory Syncytial Virus: The Influence of Serotype and Genotype Variability on Clinical Course of Infection. Int. J. Mol. Sci. 2017, 18, 1717.

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