Mechanosensitive miRNAs and Bone Formation
AbstractMechanical stimuli are required for the maintenance of skeletal integrity and bone mass. An increasing amount of evidence indicates that multiple regulators (e.g., hormone, cytoskeleton proteins and signaling pathways) are involved in the mechanical stimuli modulating the activities of osteogenic cells and the process of bone formation. Significantly, recent studies have showed that several microRNAs (miRNAs) were sensitive to various mechanical stimuli and played a crucial role in osteogenic differentiation and bone formation. However, the functional roles and further mechanisms of mechanosensitive miRNAs in bone formation are not yet completely understood. This review highlights the roles of mechanosensitive miRNAs in osteogenic differentiation and bone formation and underlines their potential therapeutic application for bone loss induced by the altering of mechanical stimuli. View Full-Text
Share & Cite This Article
Chen, Z.; Zhang, Y.; Liang, C.; Chen, L.; Zhang, G.; Qian, A. Mechanosensitive miRNAs and Bone Formation. Int. J. Mol. Sci. 2017, 18, 1684.
Chen Z, Zhang Y, Liang C, Chen L, Zhang G, Qian A. Mechanosensitive miRNAs and Bone Formation. International Journal of Molecular Sciences. 2017; 18(8):1684.Chicago/Turabian Style
Chen, Zhihao; Zhang, Yan; Liang, Chao; Chen, Lei; Zhang, Ge; Qian, Airong. 2017. "Mechanosensitive miRNAs and Bone Formation." Int. J. Mol. Sci. 18, no. 8: 1684.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.