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Int. J. Mol. Sci. 2017, 18(8), 1683; doi:10.3390/ijms18081683

Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes

1,2,†
,
1,2,†
,
1,2,†
,
1,2
,
1,2,3,* , 1,2,* and 1,2,*
1
Institute of Precision Medicine and Innovative Drug Discovery, School of Chinese Medicine, Hong Kong Baptist University (HKBU), Hong Kong 999077, China
2
Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University (HKBU), Hong Kong 999077, China
3
Faculty of Materials Science and Chemical Engineering, the State Key Laboratory Base of Novel Functional Materials and Preparation Science, Ningbo University, Ningbo 315211, Zhejiang, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 10 July 2017 / Revised: 27 July 2017 / Accepted: 1 August 2017 / Published: 2 August 2017
(This article belongs to the Special Issue Aptamers)

Abstract

Nucleic acid aptamers have minimal immunogenicity, high chemical synthesis production, low cost and high chemical stability when compared with antibodies. However, the susceptibility to nuclease degradation, rapid excretion through renal filtration and insufficient binding affinity hindered their development as drug candidates for therapeutic applications. In this review, we will discuss methods to conquer these challenges and highlight recent developments of chemical modifications and technological advances that may enable early aptamers to be translated into clinical therapeutics. View Full-Text
Keywords: nucleic acid aptamer; nuclease degradation; rapid excretion; binding affinity; chemical modification nucleic acid aptamer; nuclease degradation; rapid excretion; binding affinity; chemical modification
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MDPI and ACS Style

Ni, S.; Yao, H.; Wang, L.; Lu, J.; Jiang, F.; Lu, A.; Zhang, G. Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes. Int. J. Mol. Sci. 2017, 18, 1683.

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