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Int. J. Mol. Sci. 2017, 18(8), 1673; doi:10.3390/ijms18081673

Influenza A Virus–Host Protein Interactions Control Viral Pathogenesis

156 McElroy Hall, Department of Physiological Sciences, Oklahoma State University, Stillwater, OK 74078, USA
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Received: 18 June 2017 / Revised: 27 July 2017 / Accepted: 28 July 2017 / Published: 1 August 2017
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Abstract

The influenza A virus (IAV), a member of the Orthomyxoviridae family, is a highly transmissible respiratory pathogen and represents a continued threat to global health with considerable economic and social impact. IAV is a zoonotic virus that comprises a plethora of strains with different pathogenic profiles. The different outcomes of viral pathogenesis are dependent on the engagement between the virus and the host cellular protein interaction network. The interactions may facilitate virus hijacking of host molecular machinery to fulfill the viral life cycle or trigger host immune defense to eliminate the virus. In recent years, much effort has been made to discover the virus–host protein interactions and understand the underlying mechanisms. In this paper, we review the recent advances in our understanding of IAV–host interactions and how these interactions contribute to host defense and viral pathogenesis. View Full-Text
Keywords: flu; protein interactome; virus–host interactions; host defense; virulence flu; protein interactome; virus–host interactions; host defense; virulence
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhao, M.; Wang, L.; Li, S. Influenza A Virus–Host Protein Interactions Control Viral Pathogenesis. Int. J. Mol. Sci. 2017, 18, 1673.

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