Next Article in Journal
Influenza A Virus–Host Protein Interactions Control Viral Pathogenesis
Next Article in Special Issue
Daytime-Dependent Changes of Cannabinoid Receptor Type 1 and Type 2 Expression in Rat Liver
Previous Article in Journal
Toll-Like Receptor-4 Inhibitor TAK-242 Attenuates Motor Dysfunction and Spinal Cord Pathology in an Amyotrophic Lateral Sclerosis Mouse Model
Previous Article in Special Issue
Entrainment of Breast Cell Lines Results in Rhythmic Fluctuations of MicroRNAs
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2017, 18(8), 1670; doi:10.3390/ijms18081670

Variation within Variation: Comparison of 24-h Rhythm in Rodent Infarct Size between Ischemia Reperfusion and Permanent Ligation

1
Department of Cardiology, University Medical Center Utrecht, 3508GA Utrecht, The Netherlands
2
Department of Medical Physiology, University Medical Center Utrecht, 3508GA Utrecht, The Netherlands
3
Regenerative Medicine Center, University Medical Center Utrecht, 3508GA Utrecht, The Netherlands
*
Author to whom correspondence should be addressed.
Received: 4 July 2017 / Revised: 25 July 2017 / Accepted: 27 July 2017 / Published: 1 August 2017
(This article belongs to the Special Issue Molecular and Cellular Mechanisms of Circadian Rhythms)
View Full-Text   |   Download PDF [2532 KB, uploaded 1 August 2017]   |  

Abstract

The detrimental effects of myocardial infarction in humans and rodents have a 24-h rhythm. In some human cohorts however, rhythmicity was absent, while the time of maximum damage differs between cohorts. We hypothesized that the type of damage influences the 24-h rhythm in infarct size. Myocardial infarction was induced in 12-week-old C57BL/six mice at four different time-points during the day using either permanent ligation (PL) or 30-min of ischemia followed by reperfusion (IR), with a control group wherein no ligation was applied. Infarct size was measured by echocardiography and histology at a 1-month follow-up. Rhythmicity in infarct size was present in the PL group at the functional and histological level, with maximal damage occurring when the infarct was induced at noon. In the IR group, no circadian rhythm was found. The time of the coronary artery ligation determines the outcome of myocardial infarction. Our data showed that in rodents, the presence of circadian rhythmicity and time of peak infarct size varies between experimental setups. View Full-Text
Keywords: myocardial infarction; circadian; 24-h; rhythm; permanent ligation; reperfusion; reperfusion damage; infarct myocardial infarction; circadian; 24-h; rhythm; permanent ligation; reperfusion; reperfusion damage; infarct
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

du Pré, B.; Van Veen, T.; Crnko, S.; Vos, M.; Deddens, J.; Doevendans, P.; Van Laake, L. Variation within Variation: Comparison of 24-h Rhythm in Rodent Infarct Size between Ischemia Reperfusion and Permanent Ligation. Int. J. Mol. Sci. 2017, 18, 1670.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top