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Int. J. Mol. Sci. 2017, 18(8), 1639; doi:10.3390/ijms18081639

Drug Discovery by Molecular Imaging and Monitoring Therapy Response in Lymphoma

Department of Nuclear Medicine, Kyungpook National University School of Medicine and Hospital, 50, Samduk-dong 2-ga, Jung Gu, Daegu 700-721, Korea
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Received: 14 June 2017 / Revised: 23 July 2017 / Accepted: 23 July 2017 / Published: 27 July 2017
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

Molecular imaging allows a noninvasive assessment of biochemical and biological processes in living subjects. Treatment strategies for malignant lymphoma depend on histology and tumor stage. For the last two decades, molecular imaging has been the mainstay diagnostic test for the staging of malignant lymphoma and the assessment of response to treatment. This technology enhances our understanding of disease and drug activity during preclinical and clinical drug development. Here, we review molecular imaging applications in drug development, with an emphasis on oncology. Monitoring and assessing the efficacy of anti-cancer therapies in preclinical or clinical models are essential and the multimodal molecular imaging approach may represent a new stage for pharmacologic development in cancer. Monitoring the progress of lymphoma therapy with imaging modalities will help patients. Identifying and addressing key challenges is essential for successful integration of molecular imaging into the drug development process. In this review, we highlight the general usefulness of molecular imaging in drug development and radionuclide-based reporter genes. Further, we discuss the different molecular imaging modalities for lymphoma therapy and their preclinical and clinical applications. View Full-Text
Keywords: lymphoma; molecular imaging; drugs; PET-CT; bioluminescence lymphoma; molecular imaging; drugs; PET-CT; bioluminescence
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kalimuthu, S.; Jeong, J.H.; Oh, J.M.; Ahn, B.-C. Drug Discovery by Molecular Imaging and Monitoring Therapy Response in Lymphoma. Int. J. Mol. Sci. 2017, 18, 1639.

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