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Int. J. Mol. Sci. 2017, 18(8), 1617; doi:10.3390/ijms18081617

Interactions between the Kynurenine and the Endocannabinoid System with Special Emphasis on Migraine

1
MTA-SZTE Neuroscience Research Group, University of Szeged, H-6725 Szeged, Hungary
2
Faculty of Health Sciences and Social Studies, University of Szeged, H-6726 Szeged, Hungary
3
Institute of Biochemistry, Biological Research Center, Hungarian Academy of Sciences, H-6726 Szeged, Hungary
4
Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Clinical Center, University of Szeged, H-6725 Szeged, Hungary
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 30 June 2017 / Revised: 18 July 2017 / Accepted: 21 July 2017 / Published: 30 July 2017
(This article belongs to the Special Issue Cannabinoid Signaling in Nervous System)
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Abstract

Both the kynurenine and the endocannabinoid systems are involved in several neurological disorders, such as migraine and there are increasing number of reports demonstrating that there are interactions of two systems. Although their cooperation has not yet been implicated in migraine, there are reports suggesting this possibility. Additionally, the individual role of the endocannabinoid and kynurenine system in migraine is reviewed here first, focusing on endocannabinoids, kynurenine metabolites, in particular kynurenic acid. Finally, the function of NMDA and cannabinoid receptors in the trigeminal system—which has a crucial role in the pathomechanisms of migraine—will also be discussed. The interaction of the endocannabinoid and kynurenine system has been demonstrated to be therapeutically relevant in a number of pathological conditions, such as cannabis addiction, psychosis, schizophrenia and epilepsy. Accordingly, the cross-talk of these two systems may imply potential mechanisms related to migraine, and may offer new approaches to manage the treatment of this neurological disorder. View Full-Text
Keywords: cannabinoids; endocannabinoids; cannabinoid receptors; kynurenines; opioids; migraine cannabinoids; endocannabinoids; cannabinoid receptors; kynurenines; opioids; migraine
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Nagy-Grócz, G.; Zádor, F.; Dvorácskó, S.; Bohár, Z.; Benyhe, S.; Tömböly, C.; Párdutz, Á.; Vécsei, L. Interactions between the Kynurenine and the Endocannabinoid System with Special Emphasis on Migraine. Int. J. Mol. Sci. 2017, 18, 1617.

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