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Int. J. Mol. Sci. 2017, 18(8), 1601; doi:10.3390/ijms18081601

Updated Insight into the Physiological and Pathological Roles of the Retromer Complex

1
State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, College of Life Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
2
College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou 350002, China
*
Authors to whom correspondence should be addressed.
Received: 16 June 2017 / Revised: 20 July 2017 / Accepted: 21 July 2017 / Published: 25 July 2017
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [654 KB, uploaded 25 July 2017]   |  

Abstract

Retromer complexes mediate protein trafficking from the endosomes to the trans-Golgi network (TGN) or through direct recycling to the plasma membrane. In yeast, they consist of a conserved trimer of the cargo selective complex (CSC), Vps26–Vps35–Vps29 and a dimer of sorting nexins (SNXs), Vps5–Vps17. In mammals, the CSC interacts with different kinds of SNX proteins in addition to the mammalian homologues of Vps5 and Vps17, which further diversifies retromer functions. The retromer complex plays important roles in many cellular processes including restriction of invading pathogens. In this review, we summarize some recent developments in our understanding of the physiological and pathological functions of the retromer complex. View Full-Text
Keywords: retromer; receptors; vacuolar protein sorting; endosome; disease retromer; receptors; vacuolar protein sorting; endosome; disease
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Abubakar, Y.S.; Zheng, W.; Olsson, S.; Zhou, J. Updated Insight into the Physiological and Pathological Roles of the Retromer Complex. Int. J. Mol. Sci. 2017, 18, 1601.

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