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Int. J. Mol. Sci. 2017, 18(7), 1531; doi:10.3390/ijms18071531

Sustained Low Serum Substance P Levels in Non-Surviving Septic Patients

1
Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s/n. La Laguna, Tenerife 38320, Spain
2
Intensive Care Unit, Hospital Universitario Nuestra Señora Candelaria, Crta Rosario s/n. Santa Cruz Tenerife 38010, Spain
3
Laboratory Deparment, Hospital Universitario de Canarias, Ofra, s/n. La Laguna, Tenerife 38320, Spain
4
Intensive Care Unit, Hospital Clínico Universitario de Valencia, Avda, Blasco Ibáñez n° 17-19, Valencia 46004, Spain
5
Intensive Care Unit, Hospital Universitario Dr. Negrín, Barranco de la Ballena s/n. Las Palmas de Gran Canaria 35010, Spain
6
Intensive Care Unit, Hospital San Jorge de Huesca, Avenida Martínez de Velasco n° 36, Huesca 22004, Spain
7
Intensive Care Unit, Hospital Insular, Plaza Dr. Pasteur s/n. Las Palmas de Gran Canaria 35016, Spain
8
Research Unit, Hospital Universitario de Canarias, Ofra, s/n. La Laguna, Tenerife 38320, Spain
*
Author to whom correspondence should be addressed.
Received: 29 May 2017 / Revised: 12 July 2017 / Accepted: 13 July 2017 / Published: 15 July 2017
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
View Full-Text   |   Download PDF [1340 KB, uploaded 15 July 2017]   |  

Abstract

Previously, researchers found higher serum substance P (SP) concentrations in survivors of severe sepsis than in non-survivors at the time of severe sepsis diagnosis. The objectives of our current study were to determine whether there is an association between serum SP levels during the first week and sepsis mortality, sepsis severity, serum levels of tumor necrosis factor (TNF)-α and interleukin (IL)-10, and whether serum SP levels during the first week could be used as a biomarker of sepsis mortality. We determined serum concentration of SP, TNF-α, and IL-10 at days 1, 4, and 8. The end-point of the study was mortality at 30 days. We found that non-survivor (n = 104) compared to survivor patients (n = 206) showed lower serum SP levels at days 1, 4, and 8 (p < 0.001). Multiple logistic regression analyses showed an association between 30-day mortality and serum SP levels at days 1, 4, and 8 (p < 0.001) controlling for SOFA score, diabetes mellitus, age, and lactic acid levels. The most interesting findings of our study were that there is an association between serum SP levels during the first week and sepsis mortality, and that serum SP levels during the first week could be used as a biomarker of sepsis mortality. View Full-Text
Keywords: substance P; patients; sepsis; mortality; outcome substance P; patients; sepsis; mortality; outcome
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lorente, L.; Martín, M.M.; Pérez-Cejas, A.; Ferreres, J.; Solé-Violán, J.; Labarta, L.; Díaz, C.; Jiménez, A. Sustained Low Serum Substance P Levels in Non-Surviving Septic Patients. Int. J. Mol. Sci. 2017, 18, 1531.

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