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Int. J. Mol. Sci. 2017, 18(7), 1490; doi:10.3390/ijms18071490

Obesity and Asthma: A Missing Link

1
Pediatric Unit, Hospital Materno-infantil, Ciudad sanitaria Virgen de las Nieves, 18014 Granada, Spain
2
Investigación Biosanitaria ibs, 18012 Granada, Spain
3
Pediatry Unit, San Cecilio University Hospital, 18012 Granada, Spain
4
Departmennt of Microbiology, Complejo Hospitalario de Granada, 18012 Granada, Spain
5
Pediatric Allergology, Hospital Materno-infantil, Ciudad sanitaria Virgen de las Nieves, 18014 Granada, Spain
6
Department of Biochemistry and Molecular Biology II, School of Pharmacy, Institute of Nutrition and Food Technology “José Mataix”, Biomedical Research Center, University of Granada, 18100 Armilla, Spain
7
CIBEROBN (Physiopathology of Obesity and Nutrition CB12/03/30038), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
*
Author to whom correspondence should be addressed.
Received: 15 June 2017 / Revised: 3 July 2017 / Accepted: 8 July 2017 / Published: 11 July 2017
(This article belongs to the Special Issue Adipokines)
View Full-Text   |   Download PDF [735 KB, uploaded 11 July 2017]   |  

Abstract

Obesity and asthma are two chronic conditions that affect millions of people. Genetic and lifestyle factors such as diet, physical activity, and early exposure to micro-organisms are important factors that may contribute to the escalating prevalence of both conditions. The prevalence of asthma is higher in obese individuals. Recently, two major phenotypes of asthma with obesity have been described: one phenotype of early-onset asthma that is aggravated by obesity, and a second phenotype of later-onset asthma that predominantly affects women. Systemic inflammation and mechanical effect, both due to the expansion of the adipose tissue, have been proposed as the main reasons for the association between obesity and asthma. However, the mechanisms involved are not yet fully understood. Moreover, it has also been suggested that insulin resistance syndrome can have a role in the association between these conditions. The intestinal microbiota is an important factor in the development of the immune system, and can be considered a link between obesity and asthma. In the obese state, higher lipopolysaccharide (LPS) serum levels as a consequence of a microbiota dysbiosis have been found. In addition, changes in microbiota composition result in a modification of carbohydrate fermentation capacity, therefore modifying short chain fatty acid (SCFA) levels. The main objective of this review is to summarize the principal findings that link obesity and asthma. View Full-Text
Keywords: obesity; asthma; gastrointestinal microbiome; adipokines obesity; asthma; gastrointestinal microbiome; adipokines
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Gomez-Llorente, M.A.; Romero, R.; Chueca, N.; Martinez-Cañavate, A.; Gomez-Llorente, C. Obesity and Asthma: A Missing Link. Int. J. Mol. Sci. 2017, 18, 1490.

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