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Int. J. Mol. Sci. 2017, 18(7), 1448; doi:10.3390/ijms18071448

New Insights into the Role of Matrix Metalloproteinases in Preeclampsia

1
Clinical Research Branch, Instituto Nacional de Perinatologia, Mexico City 11000, Mexico
2
Department of Immunobiochemistry, Instituto Nacional de Perinatologia, Mexico City 11000, Mexico
3
Unidad de Vinculacion de la Facultad de Medicina, UNAM en el Instituto Nacional de Medicina Genomica, Mexico City 14610, Mexico
4
Guadalupe Estrada-Gutierrez, Research Division, Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City 11000, Mexico
*
Author to whom correspondence should be addressed.
Received: 10 May 2017 / Revised: 30 June 2017 / Accepted: 1 July 2017 / Published: 20 July 2017
(This article belongs to the Special Issue Metalloproteins 2017)
View Full-Text   |   Download PDF [613 KB, uploaded 20 July 2017]   |  

Abstract

Preeclampsia is a severe pregnancy complication globally, characterized by poor placentation triggering vascular dysfunction. Matrix metalloproteinases (MMPs) exhibit proteolytic activity implicated in the efficiency of trophoblast invasion to the uterine wall, and a dysregulation of these enzymes has been linked to preeclampsia. A decrease in MMP-2 and MMP-9 interferes with the normal remodeling of spiral arteries at early pregnancy stages, leading to the initial pathophysiological changes observed in preeclampsia. Later in pregnancy, an elevation in MMP-2 and MMP-9 induces abnormal release of vasoactive factors conditioning hypertension. Although these two enzymes lead the scene, other MMPs like MMP-1 and MMP-14 seem to have a role in this pathology. This review gathers published recent evidence about the implications of different MMPs in preeclampsia, and the potential use of these enzymes as emergent biomarkers and biological therapeutic targets, focusing on studies involving human subjects. View Full-Text
Keywords: preeclampsia; implantation; matrix metalloproteinases; trophoblast; endothelial damage; biomarkers; therapeutic targets preeclampsia; implantation; matrix metalloproteinases; trophoblast; endothelial damage; biomarkers; therapeutic targets
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Espino Y. Sosa, S.; Flores-Pliego, A.; Espejel-Nuñez, A.; Medina-Bastidas, D.; Vadillo-Ortega, F.; Zaga-Clavellina, V.; Estrada-Gutierrez, G. New Insights into the Role of Matrix Metalloproteinases in Preeclampsia. Int. J. Mol. Sci. 2017, 18, 1448.

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