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Int. J. Mol. Sci. 2017, 18(7), 1444; doi:10.3390/ijms18071444

Lack of Association between Hepatitis C Virus core Gene Variation 70/91aa and Insulin Resistance

1
Livia Melo Villar, Viral Hepatitis Laboratory, Helio and Peggy Pereira Pavilion, Ground Floor, Room B09, FIOCRUZ Av. Brasil, 4365-Manguinhos, Rio de Janeiro, RJ 210360-040, Brazil
2
Gaffrée & Guinle University Hospital, Federal University of Rio de Janeiro State, Rio de Janeiro, RJ 20270-001, Brazil
3
University Hospital Clementino Fraga Filho, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-913, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Tatsuo Kanda
Received: 31 March 2017 / Revised: 17 May 2017 / Accepted: 24 May 2017 / Published: 21 July 2017
(This article belongs to the Special Issue Hepatitis Virus Infection and Research)
View Full-Text   |   Download PDF [411 KB, uploaded 21 July 2017]   |  

Abstract

The role of hepatitis C virus (HCV) in insulin resistance (IR) is not fully understood. The aim of this study was to determine the impact of amino acid (aa) substitutions in the core region of HCV according to IR and to identify clinical and laboratory associations. Ninety-two treatment-naive HCV patients were recruited to determine laboratory data and blood cell count. IR was determined using Homeostasis Model Assessment (HOMA) index where IR was defined as HOMA ≥2. HCV RNA load and genotype were determined by Abbott Real time HCV. HCV core region was determined by direct nucleotide sequencing. Bivariate analysis was conducted using HOMA IR ≥2 as a dependent factor. IR prevalence was 43.5% (n = 40), vitamin D sufficiency was found in 76.1% (n = 70) and 72.8% (n = 67) had advanced liver fibrosis. In the bivariate analyses, elevated values of γGT (p = 0.024) and fibrosis staging (p = 0.004) were associated with IR, but IR was not related to core mutations. The presence of glutamine in position 70 was associated with low vitamin D concentration (p = 0.005). In the multivariate analysis, no variable was independently associated with HOMA-IR. In conclusion, lack of association between IR and HCV core mutations in positions 70 and 91 suggests that genetic variability of this region has little impact on IR. View Full-Text
Keywords: amino acid; core mutation; insulin resistance; hepatitis C amino acid; core mutation; insulin resistance; hepatitis C
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MDPI and ACS Style

Scalioni, L.P.; da Silva, A.P.; Miguel, J.C.; Espírito Santo, M.P.; Marques, V.A.; Brandão-Mello, C.E.; Villela-Nogueira, C.A.; Lewis-Ximenez, L.L.; Lampe, E.; Villar, L.M. Lack of Association between Hepatitis C Virus core Gene Variation 70/91aa and Insulin Resistance. Int. J. Mol. Sci. 2017, 18, 1444.

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