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Int. J. Mol. Sci. 2017, 18(7), 1426; doi:10.3390/ijms18071426

Effect of Oxidative Stress on Cardiovascular System in Response to Gravity

1
Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan
2
Department of Medicine, Okayama University, Okayama 700-8558, Japan
3
Department of Cardiovascular Surgery, Harbin Medical University, Harbin 150001, China
*
Author to whom correspondence should be addressed.
Received: 1 June 2017 / Revised: 26 June 2017 / Accepted: 27 June 2017 / Published: 4 July 2017
(This article belongs to the Special Issue Oxidative Stress and Space Biology: An Organ-Based Approach)
View Full-Text   |   Download PDF [390 KB, uploaded 4 July 2017]   |  

Abstract

Long-term habitation in space leads to physiological alterations such as bone loss, muscle atrophy, and cardiovascular deconditioning. Two predominant factors—namely space radiation and microgravity—have a crucial impact on oxidative stress in living organisms. Oxidative stress is also involved in the aging process, and plays important roles in the development of cardiovascular diseases including hypertension, left ventricular hypertrophy, and myocardial infarction. Here, we discuss the effects of space radiation, microgravity, and a combination of these two factors on oxidative stress. Future research may facilitate safer living in space by reducing the adverse effects of oxidative stress. View Full-Text
Keywords: oxidative stress; reactive oxygen species; radiation; microgravity oxidative stress; reactive oxygen species; radiation; microgravity
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Takahashi, K.; Okumura, H.; Guo, R.; Naruse, K. Effect of Oxidative Stress on Cardiovascular System in Response to Gravity. Int. J. Mol. Sci. 2017, 18, 1426.

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