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Int. J. Mol. Sci. 2017, 18(7), 1404; doi:10.3390/ijms18071404

Histone Lysine Methylation and Neurodevelopmental Disorders

1
Personalized Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea
2
Department of Functional Genomics, University of Science and Technology, Daejeon 34113, Korea
3
Department of Biological Sciences, Konkuk University, Seoul 05029, Korea
4
Department of Brain & Cognitive Sciences, DGIST, Daegu 42988, Korea
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 13 June 2017 / Revised: 25 June 2017 / Accepted: 27 June 2017 / Published: 30 June 2017
(This article belongs to the Special Issue Epigenetics of Neurodevelopmental Disorders)
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Abstract

Methylation of several lysine residues of histones is a crucial mechanism for relatively long-term regulation of genomic activity. Recent molecular biological studies have demonstrated that the function of histone methylation is more diverse and complex than previously thought. Moreover, studies using newly available genomics techniques, such as exome sequencing, have identified an increasing number of histone lysine methylation-related genes as intellectual disability-associated genes, which highlights the importance of accurate control of histone methylation during neurogenesis. However, given the functional diversity and complexity of histone methylation within the cell, the study of the molecular basis of histone methylation-related neurodevelopmental disorders is currently still in its infancy. Here, we review the latest studies that revealed the pathological implications of alterations in histone methylation status in the context of various neurodevelopmental disorders and propose possible therapeutic application of epigenetic compounds regulating histone methylation status for the treatment of these diseases. View Full-Text
Keywords: epigenetic changes; histone lysine methylation; lysine methyltransferase; lysine demethylase; neurodevelopmental disorder epigenetic changes; histone lysine methylation; lysine methyltransferase; lysine demethylase; neurodevelopmental disorder
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Kim, J.-H.; Lee, J.H.; Lee, I.-S.; Lee, S.B.; Cho, K.S. Histone Lysine Methylation and Neurodevelopmental Disorders. Int. J. Mol. Sci. 2017, 18, 1404.

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