RNA Binding Proteins and Genome Integrity
AbstractGenome integrity can be threatened by various endogenous or exogenous events. To counteract these stressors, the DNA damage response network contributes to the prevention and/or repair of genomic DNA damage and serves an essential function in cellular survival. DNA binding proteins are involved in this network. Recently, several RNA-binding proteins (RBPs) that are recruited to DNA damage sites have been shown to be direct players in the prevention or repair of DNA damage. In addition, non-coding RNAs, themselves, are involved in the RNA-mediated DNA repair system. Furthermore, RNA modification such as m6A methylation might also contribute to the ultraviolet-responsive DNA damage response. Accumulating evidence suggests that RNA metabolism is more deeply involved in diverse cellular functions than previously expected, and is also intricately associated with the maintenance of genome integrity. In this review, we highlight the roles of RBPs in the maintenance of genome integrity. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Nishida, K.; Kuwano, Y.; Nishikawa, T.; Masuda, K.; Rokutan, K. RNA Binding Proteins and Genome Integrity. Int. J. Mol. Sci. 2017, 18, 1341.
Nishida K, Kuwano Y, Nishikawa T, Masuda K, Rokutan K. RNA Binding Proteins and Genome Integrity. International Journal of Molecular Sciences. 2017; 18(7):1341.Chicago/Turabian Style
Nishida, Kensei; Kuwano, Yuki; Nishikawa, Tatsuya; Masuda, Kiyoshi; Rokutan, Kazuhito. 2017. "RNA Binding Proteins and Genome Integrity." Int. J. Mol. Sci. 18, no. 7: 1341.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.