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Int. J. Mol. Sci. 2017, 18(6), 1277; doi:10.3390/ijms18061277

Evolving Identification of Blood Cells Associated with Clinically Isolated Syndrome: Importance of Time since Clinical Presentation and Diagnostic MRI

1
Telethon Kids Institute, University of Western Australia, Perth, WA 6008, Australia
2
Cellular Photoimmunology Group, Infectious Diseases & Immunology, Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, Australia
3
Centre for Immunology and Allergy Research, Westmead Institute for Medical Research, University of Sydney, Sydney, NSW 2006, Australia
4
Centre for Neuromuscular and Neurological Disorders, Perron Institute for Neurological and Translational Science, University of Western Australia, Sir Charles Gairdner Hospital, Perth, WA 6009, Australia
5
Immunology Department, Royal Perth Hospital, Perth, WA 6000, Australia
6
Institute for Immunology and Infectious Disease, Murdoch University, Perth, WA 6150, Australia
7
National Centre for Epidemiology & Population Health, Research School of Population Health, Australian National University, Canberra, ACT 0200, Australia
*
Author to whom correspondence should be addressed.
Received: 28 April 2017 / Revised: 29 May 2017 / Accepted: 12 June 2017 / Published: 15 June 2017
(This article belongs to the Special Issue Advances in Multiple Sclerosis 2017)
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Abstract

It is not clear how the profile of immune cells in peripheral blood differs between patients with clinically isolated syndrome (CIS) and healthy controls (HC). This study aimed to identify a CIS peripheral blood signature that may provide clues for potential immunomodulatory approaches early in disease. Peripheral blood mononuclear cells (PBMCs) were collected from 18 people with CIS, 19 HC and 13 individuals with other demyelinating conditions (ODC) including multiple sclerosis (MS). Individuals with CIS separated into two groups, namely those with early (≤14 days post-diagnostic magnetic resonance imaging (MRI); n = 6) and late (≥27 days; n = 12) blood sampling. Transitional B cells were increased in the blood of CIS patients independently of when blood was taken. However, there were two time-dependent effects found in the late CIS group relative to HC, including decreased CD56bright NK cells, which correlated significantly with time since MRI, and increased CD141+ myeloid dendritic cell (mDC2) frequencies. Higher CD1c+ B cells and lower non-classical monocyte frequencies were characteristic of more recent demyelinating disease activity (ODC and early CIS). Analysing cell populations by time since symptoms (subjective) and diagnostic MRI (objective) may contribute to understanding CIS. View Full-Text
Keywords: multiple sclerosis; clinically isolated syndrome; immunology; pathology; B cells; NK cells multiple sclerosis; clinically isolated syndrome; immunology; pathology; B cells; NK cells
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MDPI and ACS Style

Trend, S.; Jones, A.P.; Geldenhuys, S.; Byrne, S.N.; Fabis-Pedrini, M.J.; Nolan, D.; Booth, D.R.; Carroll, W.M.; Lucas, R.M.; Kermode, A.G.; Hart, P.H. Evolving Identification of Blood Cells Associated with Clinically Isolated Syndrome: Importance of Time since Clinical Presentation and Diagnostic MRI. Int. J. Mol. Sci. 2017, 18, 1277.

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