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Int. J. Mol. Sci. 2017, 18(6), 1272; doi:10.3390/ijms18061272

Osteoblast Role in Rheumatic Diseases

Rheumatology Clinic, Department of Medical and Surgical Sciences, University of Foggia Medical School, 71122 Foggia, Italy
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Received: 14 May 2017 / Revised: 7 June 2017 / Accepted: 12 June 2017 / Published: 15 June 2017
(This article belongs to the Special Issue Advances in Bone and Cartilage Research)
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Abstract

Alterations in osteoblast growth, differentiation and activity play a role in the pathogenesis of several rheumatic diseases, such as rheumatoid arthritis, spondyloarthritides, osteoarthritis, and osteoporosis. In fact, in these rheumatic diseases, abnormal activity of Wnt signaling, receptor activator of nuclear factor-κB (RANK)-RANK ligand (RANKL)-osteoprotegerin (OPG) signaling, bone morphogenetic proteins (BMPs) pathway and other mechanisms have been described in osteoblasts. This review article is focused on current knowledge on the role of osteoblast dysregulation occurring in rheumatic diseases. View Full-Text
Keywords: arthritis; osteoarthritis; osteoblast; osteoporosis; spondyloarthritis arthritis; osteoarthritis; osteoblast; osteoporosis; spondyloarthritis
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Corrado, A.; Maruotti, N.; Cantatore, F.P. Osteoblast Role in Rheumatic Diseases. Int. J. Mol. Sci. 2017, 18, 1272.

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