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Int. J. Mol. Sci. 2017, 18(6), 1241; doi:10.3390/ijms18061241

The Implication of Substance P in the Development of Tendinopathy: A Case Control Study

Department of Orthopedic Surgery, CHA Bundang Medical Center, CHA University, Gyeonggi-do 13496, Korea
Institute for Clinical Research, Department of Orthopedic Surgery, CHA Bundang Medical Center, CHA University, Gyeonggi-do 13496, Korea
Department of Pathology, CHA Bundang Medical Center, CHA University School of Medicine, Gyeonggi-do 13496, Korea
Division of Growth and Development and Section of Orthodontics, School of Dentistry, University of California, Los Angeles, CA 90095, USA
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Gehua Zhen
Received: 17 March 2017 / Revised: 25 May 2017 / Accepted: 6 June 2017 / Published: 9 June 2017
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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It was reported that substance P had beneficial effects in the healing of acute tendon injury. However, the relationship between substance P and degenerative tendinopathy development remains unclear. The purpose of this study was to determine the role of substance P in the pathogenesis of tendinopathy. Healthy and tendinopathy tendon were harvested from human and tenocytes were cultured individually. The expression levels of genes associated with tendinopathy were compared. Next, substance P was exogenously administered to the healthy tenocyte and the effect was evaluated. The results showed that tendinopathy tenocytes had higher levels of COL3A1, MMP1, COX2, SCX, ACTA2, and substance P gene expression compared to healthy tenocytes. Next, substance P treatment on the healthy tenocyte displayed similar changes to that of the tendinopathy tenocytes. These differences between the two groups were also determined by Western blot. Additionally, cells with substance P had the tendinopathy change morphologically although cellular proliferation was significantly higher compared to that of the control group. In conclusion, substance P enhanced cellular proliferation, but concomitantly increased immature collagen (type 3 collagen). Substance P plays a crucial role in tendinopathy development and could be a future therapeutic target for treatment. View Full-Text
Keywords: tendinopathy; pathogenesis; substance P; type 3 collagen tendinopathy; pathogenesis; substance P; type 3 collagen

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Han, S.-H.; Choi, W.; Song, J.; Kim, J.; Lee, S.; Choi, Y.; Byun, S.-E.; Ahn, T.; Ahn, H.; Ding, C.; Baik, L.; Ward, S.; Ting, K.; Lee, S. The Implication of Substance P in the Development of Tendinopathy: A Case Control Study. Int. J. Mol. Sci. 2017, 18, 1241.

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Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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