The Implication of Substance P in the Development of Tendinopathy: A Case Control Study
AbstractIt was reported that substance P had beneficial effects in the healing of acute tendon injury. However, the relationship between substance P and degenerative tendinopathy development remains unclear. The purpose of this study was to determine the role of substance P in the pathogenesis of tendinopathy. Healthy and tendinopathy tendon were harvested from human and tenocytes were cultured individually. The expression levels of genes associated with tendinopathy were compared. Next, substance P was exogenously administered to the healthy tenocyte and the effect was evaluated. The results showed that tendinopathy tenocytes had higher levels of COL3A1, MMP1, COX2, SCX, ACTA2, and substance P gene expression compared to healthy tenocytes. Next, substance P treatment on the healthy tenocyte displayed similar changes to that of the tendinopathy tenocytes. These differences between the two groups were also determined by Western blot. Additionally, cells with substance P had the tendinopathy change morphologically although cellular proliferation was significantly higher compared to that of the control group. In conclusion, substance P enhanced cellular proliferation, but concomitantly increased immature collagen (type 3 collagen). Substance P plays a crucial role in tendinopathy development and could be a future therapeutic target for treatment. View Full-Text
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Han, S.-H.; Choi, W.; Song, J.; Kim, J.; Lee, S.; Choi, Y.; Byun, S.-E.; Ahn, T.; Ahn, H.; Ding, C.; Baik, L.; Ward, S.; Ting, K.; Lee, S. The Implication of Substance P in the Development of Tendinopathy: A Case Control Study. Int. J. Mol. Sci. 2017, 18, 1241.
Han S-H, Choi W, Song J, Kim J, Lee S, Choi Y, Byun S-E, Ahn T, Ahn H, Ding C, Baik L, Ward S, Ting K, Lee S. The Implication of Substance P in the Development of Tendinopathy: A Case Control Study. International Journal of Molecular Sciences. 2017; 18(6):1241.Chicago/Turabian Style
Han, Soo-Hong; Choi, Wonchul; Song, Jiye; Kim, Jaehee; Lee, Seungyong; Choi, Youngrak; Byun, Seong-Eun; Ahn, Taekeun; Ahn, Heejung; Ding, Catherine; Baik, Lloyd; Ward, Spencer; Ting, Kang; Lee, Soonchul. 2017. "The Implication of Substance P in the Development of Tendinopathy: A Case Control Study." Int. J. Mol. Sci. 18, no. 6: 1241.