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Int. J. Mol. Sci. 2017, 18(6), 1239; doi:10.3390/ijms18061239

Genomic Insight into the Role of lncRNAs in Cancer Susceptibility

Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu 90014, Finland
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Received: 23 May 2017 / Revised: 6 June 2017 / Accepted: 7 June 2017 / Published: 9 June 2017
(This article belongs to the Special Issue Cancer Epigenetics)
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Abstract

With the development of advanced genomic methods, a large amount of long non-coding RNAs (lncRNAs) have been found to be important for cancer initiation and progression. Given that most of the genome-wide association study (GWAS)-identified cancer risk SNPs are located in the noncoding region, the expression and function of lncRNAs are more likely to be affected by the SNPs. The SNPs may affect the expression of lncRNAs directly through disrupting the binding of transcription factors or indirectly by affecting the expression of regulatory factors. Moreover, SNPs may disrupt the interaction between lncRNAs and other RNAs orproteins. Unveiling the relationship of lncRNA, protein-coding genes, transcription factors and miRNAs from the angle of genomics will improve the accuracy of disease prediction and help find new therapeutic targets. View Full-Text
Keywords: lncRNA; GWAS; genomics; transcription factor; SNP; cancer lncRNA; GWAS; genomics; transcription factor; SNP; cancer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Gao, P.; Wei, G.-H. Genomic Insight into the Role of lncRNAs in Cancer Susceptibility. Int. J. Mol. Sci. 2017, 18, 1239.

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