Genomic Insight into the Role of lncRNAs in Cancer Susceptibility
AbstractWith the development of advanced genomic methods, a large amount of long non-coding RNAs (lncRNAs) have been found to be important for cancer initiation and progression. Given that most of the genome-wide association study (GWAS)-identiﬁed cancer risk SNPs are located in the noncoding region, the expression and function of lncRNAs are more likely to be affected by the SNPs. The SNPs may affect the expression of lncRNAs directly through disrupting the binding of transcription factors or indirectly by affecting the expression of regulatory factors. Moreover, SNPs may disrupt the interaction between lncRNAs and other RNAs orproteins. Unveiling the relationship of lncRNA, protein-coding genes, transcription factors and miRNAs from the angle of genomics will improve the accuracy of disease prediction and help ﬁnd new therapeutic targets. View Full-Text
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Gao, P.; Wei, G.-H. Genomic Insight into the Role of lncRNAs in Cancer Susceptibility. Int. J. Mol. Sci. 2017, 18, 1239.
Gao P, Wei G-H. Genomic Insight into the Role of lncRNAs in Cancer Susceptibility. International Journal of Molecular Sciences. 2017; 18(6):1239.Chicago/Turabian Style
Gao, Ping; Wei, Gong-Hong. 2017. "Genomic Insight into the Role of lncRNAs in Cancer Susceptibility." Int. J. Mol. Sci. 18, no. 6: 1239.
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