The Roles of Long Non-Protein-Coding RNAs in Osteo-Adipogenic Lineage Commitment
AbstractOsteoblasts and adipocytes share a common mesenchymal progenitor in the bone marrow. This implies that a reciprocal relationship exists between osteogenic and adipogenic differentiation. Further, cells of osteoblast lineage transdifferentiate into adipocytes under some circumstances. Dysregulation of osteo-adipogenic fate-determination leads to bone diseases such as osteoporosis, accompanied by an increase in bone marrow adipose tissue. Thus, the fine-tuning of osteo-adipogenesis is necessary for bone homeostasis. Osteo-adipogenic progression is governed by a complex crosstalk of extrinsic signals, transcription factors, and epigenetic factors. Long non-protein-coding RNAs (lncRNAs) act in part as epigenetic regulators in a broad range of biological activities, such as chromatin organization, transcriptional regulation, post-translational modifications, and histone modification. In this review, we highlight the roles of epigenetic regulators, particularly lncRNAs, in the osteo-adipogenic lineage commitment of bone marrow mesenchymal stem cells and the adipogenic transdifferentiation of osteoblasts. View Full-Text
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Yoshioka, H.; Yoshiko, Y. The Roles of Long Non-Protein-Coding RNAs in Osteo-Adipogenic Lineage Commitment. Int. J. Mol. Sci. 2017, 18, 1236.
Yoshioka H, Yoshiko Y. The Roles of Long Non-Protein-Coding RNAs in Osteo-Adipogenic Lineage Commitment. International Journal of Molecular Sciences. 2017; 18(6):1236.Chicago/Turabian Style
Yoshioka, Hirotaka; Yoshiko, Yuji. 2017. "The Roles of Long Non-Protein-Coding RNAs in Osteo-Adipogenic Lineage Commitment." Int. J. Mol. Sci. 18, no. 6: 1236.
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