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Int. J. Mol. Sci. 2017, 18(6), 1236; doi:10.3390/ijms18061236

The Roles of Long Non-Protein-Coding RNAs in Osteo-Adipogenic Lineage Commitment

Department of Calcified Tissue Biology, Hiroshima University Institute of Biomedical and Health Sciences, 734-8553 Hiroshima, Japan
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Received: 15 May 2017 / Revised: 5 June 2017 / Accepted: 6 June 2017 / Published: 9 June 2017
(This article belongs to the Special Issue Advances in Bone and Cartilage Research)
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Abstract

Osteoblasts and adipocytes share a common mesenchymal progenitor in the bone marrow. This implies that a reciprocal relationship exists between osteogenic and adipogenic differentiation. Further, cells of osteoblast lineage transdifferentiate into adipocytes under some circumstances. Dysregulation of osteo-adipogenic fate-determination leads to bone diseases such as osteoporosis, accompanied by an increase in bone marrow adipose tissue. Thus, the fine-tuning of osteo-adipogenesis is necessary for bone homeostasis. Osteo-adipogenic progression is governed by a complex crosstalk of extrinsic signals, transcription factors, and epigenetic factors. Long non-protein-coding RNAs (lncRNAs) act in part as epigenetic regulators in a broad range of biological activities, such as chromatin organization, transcriptional regulation, post-translational modifications, and histone modification. In this review, we highlight the roles of epigenetic regulators, particularly lncRNAs, in the osteo-adipogenic lineage commitment of bone marrow mesenchymal stem cells and the adipogenic transdifferentiation of osteoblasts. View Full-Text
Keywords: osteoblasts; adipocytes; transdifferentiation; epigenetics; non-protein-coding RNAs osteoblasts; adipocytes; transdifferentiation; epigenetics; non-protein-coding RNAs
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Yoshioka, H.; Yoshiko, Y. The Roles of Long Non-Protein-Coding RNAs in Osteo-Adipogenic Lineage Commitment. Int. J. Mol. Sci. 2017, 18, 1236.

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