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Int. J. Mol. Sci. 2017, 18(6), 1200; doi:10.3390/ijms18061200

Ulmus macrocarpa Hance Extracts Attenuated H2O2 and UVB-Induced Skin Photo-Aging by Activating Antioxidant Enzymes and Inhibiting MAPK Pathways

1
Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 24341, Korea
2
Jeongseon Yaccho Co., Ltd., Jeongseon 26125, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Woo-Sik Jeong
Received: 6 March 2017 / Revised: 19 May 2017 / Accepted: 30 May 2017 / Published: 5 June 2017
(This article belongs to the Special Issue Nutrients and Phytochemicals for Skin Health)
View Full-Text   |   Download PDF [2558 KB, uploaded 5 June 2017]   |  

Abstract

To protect from reactive oxygen species (ROS) damages, skin cells have evolved to have antioxidant enzymes, such as copper and zinc-dependent superoxide dismutase (SOD1), mitochondrial manganese-dependent superoxide dismutase (SOD2), catalase (CAT), glutathione peroxidase (GPX), and glutathione reductase (GR), and suppressed the expression of matrix metalloproteinases (MMPs) through the mitogen-activated protein kinase (MAPK) signaling pathways, such as c-Jun N-terminal kinase (JNK) and p38. Bioactive compounds analyses were performed using a high-performance liquid chromatography-photodiode array detector (HPLC-PDA) system. The antioxidant activity of Ulmus macrocarpa Hance (UMH) extracts was estimated in vitro. The anti-aging activity of UMH extracts was estimated in vivo using the SKH-1 hairless mice. The UMH extracts reduced the H2O2-induced intracellular ROS production and the cell damages in human dermal fibroblasts (HDFs). Moreover, the H2O2-induced phosphorylation of JNK and p38 was detected in HDF and UMH extracts blocked the phosphorylation. These results suggest that UMH extracts can reduce the expression of MMPs and the reduced MMPs lead to the inhibition of collagen degradation. In addition, oral administration of the UMH extracts decreased the depth, thickness, and length of wrinkles on UVB exposed hairless mice. Therefore, UMH extracts play an advantage of the functional materials in antioxidant and anti-aging of skin. View Full-Text
Keywords: Ulmus macrocarpa Hance extracts; human dermal fibroblasts; hairless mice; antioxidant; anti-aging Ulmus macrocarpa Hance extracts; human dermal fibroblasts; hairless mice; antioxidant; anti-aging
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Choi, S.-I.; Lee, J.-H.; Kim, J.-M.; Jung, T.-D.; Cho, B.-Y.; Choi, S.-H.; Lee, D.-W.; Kim, J.; Kim, J.-Y.; Lee, O.-H. Ulmus macrocarpa Hance Extracts Attenuated H2O2 and UVB-Induced Skin Photo-Aging by Activating Antioxidant Enzymes and Inhibiting MAPK Pathways. Int. J. Mol. Sci. 2017, 18, 1200.

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