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Int. J. Mol. Sci. 2017, 18(6), 1138; doi:10.3390/ijms18061138

Perturbations in the Replication Program Contribute to Genomic Instability in Cancer

1
Department of Microbiology and Molecular Genetics, IMRIC, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel
2
Pharmacology and Experimental Therapeutics Unit, The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
*
Author to whom correspondence should be addressed.
Academic Editor: Vassilis G. Gorgoulis
Received: 6 April 2017 / Revised: 8 May 2017 / Accepted: 21 May 2017 / Published: 25 May 2017
(This article belongs to the Special Issue Mechanisms Leading to Genomic Instability)
View Full-Text   |   Download PDF [646 KB, uploaded 26 May 2017]   |  

Abstract

Cancer and genomic instability are highly impacted by the deoxyribonucleic acid (DNA) replication program. Inaccuracies in DNA replication lead to the increased acquisition of mutations and structural variations. These inaccuracies mainly stem from loss of DNA fidelity due to replication stress or due to aberrations in the temporal organization of the replication process. Here we review the mechanisms and impact of these major sources of error to the replication program. View Full-Text
Keywords: genomic instability; replication timing; replication stress; cancer genomic instability; replication timing; replication stress; cancer
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Blumenfeld, B.; Ben-Zimra, M.; Simon, I. Perturbations in the Replication Program Contribute to Genomic Instability in Cancer. Int. J. Mol. Sci. 2017, 18, 1138.

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