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Int. J. Mol. Sci. 2017, 18(6), 1136; doi:10.3390/ijms18061136

Comparative Study of Lectin Domains in Model Species: New Insights into Evolutionary Dynamics

1
Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
2
Department of Crop Protection, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Setsuko Komatsu
Received: 6 May 2017 / Revised: 20 May 2017 / Accepted: 22 May 2017 / Published: 25 May 2017
(This article belongs to the Special Issue Plant Lectins: From Model Species to Crop Plants)
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Abstract

Lectins are present throughout the plant kingdom and are reported to be involved in diverse biological processes. In this study, we provide a comparative analysis of the lectin families from model species in a phylogenetic framework. The analysis focuses on the different plant lectin domains identified in five representative core angiosperm genomes (Arabidopsis thaliana, Glycine max, Cucumis sativus, Oryza sativa ssp. japonica and Oryza sativa ssp. indica). The genomes were screened for genes encoding lectin domains using a combination of Basic Local Alignment Search Tool (BLAST), hidden Markov models, and InterProScan analysis. Additionally, phylogenetic relationships were investigated by constructing maximum likelihood phylogenetic trees. The results demonstrate that the majority of the lectin families are present in each of the species under study. Domain organization analysis showed that most identified proteins are multi-domain proteins, owing to the modular rearrangement of protein domains during evolution. Most of these multi-domain proteins are widespread, while others display a lineage-specific distribution. Furthermore, the phylogenetic analyses reveal that some lectin families evolved to be similar to the phylogeny of the plant species, while others share a closer evolutionary history based on the corresponding protein domain architecture. Our results yield insights into the evolutionary relationships and functional divergence of plant lectins. View Full-Text
Keywords: lectin; carbohydrate; evolution; phylogeny; protein domain lectin; carbohydrate; evolution; phylogeny; protein domain
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Van Holle, S.; De Schutter, K.; Eggermont, L.; Tsaneva, M.; Dang, L.; Van Damme, E.J.M. Comparative Study of Lectin Domains in Model Species: New Insights into Evolutionary Dynamics. Int. J. Mol. Sci. 2017, 18, 1136.

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