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Int. J. Mol. Sci. 2017, 18(5), 973; doi:10.3390/ijms18050973

Galectin-3 in Peripheral Artery Disease. Relationships with Markers of Oxidative Stress and Inflammation

1
Biochemical Research Unit, Hospital Universitari de Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, C. Sant Joan s/n, Reus, 43201 Catalonia, Spain
2
Reference Laboratory of Catalonia South, Hospital Universitari de Sant Joan, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Av. Cambra de Comerç 42, Reus, 43204 Catalonia, Spain
3
Service of Angiology, Vascular Surgery and Endosurgery, Hospital Universitari Joan XXIII, Institut d’Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, C. Dr. Mallafré Guasch 4, Tarragona, 43005 Catalonia, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Neal Weintraub
Received: 24 February 2017 / Revised: 6 April 2017 / Accepted: 29 April 2017 / Published: 4 May 2017
(This article belongs to the Special Issue Oxidative Stress in Vascular Diseases)
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Abstract

Galectin-3 is a modulator of oxidative stress, inflammation, and fibrogenesis involved in the pathogenesis of vascular diseases. The present study sought to characterize, in patients with peripheral artery disease (PAD), the localization of galectin-3 in arterial tissue, and to analyze the relationships between the circulating levels of galectin-3 and oxidative stress and inflammation. It also sought to compare the diagnostic accuracy of galectin-3 with that of other biochemical markers of this disease. We analyzed femoral or popliteal arteries from 50 PAD patients, and four control arteries. Plasma from 86 patients was compared with that from 72 control subjects. We observed differences in the expression of galectin-3 in normal arteries, and arteries from patients with PAD, with a displacement of the expression from the adventitia to the media, and the intima. In addition, plasma galectin-3 concentration was increased in PAD patients, and correlated with serologic markers of oxidative stress (F2-isoprostanes), and inflammation [chemokine (C−C motif) ligand 2, C-reactive protein, β-2-microglobulin]. We conclude that the determination of galectin-3 has good diagnostic accuracy in the assessment of PAD and compares well with other analytical parameters currently in use. View Full-Text
Keywords: atherosclerosis; F2-isoprostanes; galectin-3; oxidative stress; peripheral artery disease atherosclerosis; F2-isoprostanes; galectin-3; oxidative stress; peripheral artery disease
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Fort-Gallifa, I.; Hernández-Aguilera, A.; García-Heredia, A.; Cabré, N.; Luciano-Mateo, F.; Simó, J.M.; Martín-Paredero, V.; Camps, J.; Joven, J. Galectin-3 in Peripheral Artery Disease. Relationships with Markers of Oxidative Stress and Inflammation. Int. J. Mol. Sci. 2017, 18, 973.

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