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Int. J. Mol. Sci. 2017, 18(5), 960; doi:10.3390/ijms18050960

Molecular Mechanism of Quorum-Sensing in Enterococcus faecalis: Its Role in Virulence and Therapeutic Approaches

1
College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China
2
College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China
3
Department of Biosciences, Faculty of Science, COMSATS Institute of Information Technology, Islamabad 45550, Pakistan
4
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing 100101, China
*
Author to whom correspondence should be addressed.
Academic Editor: Guido R. M. M. Haenen
Received: 2 April 2017 / Accepted: 26 April 2017 / Published: 3 May 2017
(This article belongs to the Section Molecular Toxicology)
View Full-Text   |   Download PDF [1969 KB, uploaded 3 May 2017]   |  

Abstract

Quorum-sensing systems control major virulence determinants in Enterococcus faecalis, which causes nosocomial infections. The E. faecalis quorum-sensing systems include several virulence factors that are regulated by the cytolysin operon, which encodes the cytolysin toxin. In addition, the E. faecalis Fsr regulator system controls the expression of gelatinase, serine protease, and enterocin O16. The cytolysin and Fsr virulence factor systems are linked to enterococcal diseases that affect the health of humans and other host models. Therefore, there is substantial interest in understanding and targeting these regulatory pathways to develop novel therapies for enterococcal infection control. Quorum-sensing inhibitors could be potential therapeutic agents for attenuating the pathogenic effects of E. faecalis. Here, we discuss the regulation of cytolysin, the LuxS system, and the Fsr system, their role in E. faecalis-mediated infections, and possible therapeutic approaches to prevent E. faecalis infection. View Full-Text
Keywords: cytolysin; Enterococcus faecalis; Fsr; multidrug-resistant pathogen; quorum-sensing; quorum-sensing inhibitor; virulence factor cytolysin; Enterococcus faecalis; Fsr; multidrug-resistant pathogen; quorum-sensing; quorum-sensing inhibitor; virulence factor
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MDPI and ACS Style

Ali, L.; Goraya, M.U.; Arafat, Y.; Ajmal, M.; Chen, J.-L.; Yu, D. Molecular Mechanism of Quorum-Sensing in Enterococcus faecalis: Its Role in Virulence and Therapeutic Approaches. Int. J. Mol. Sci. 2017, 18, 960.

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