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Int. J. Mol. Sci. 2017, 18(5), 924; doi:10.3390/ijms18050924

Near Infrared Fluorescence Imaging in Nano-Therapeutics and Photo-Thermal Evaluation

1
Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 410210, India
2
Molecular Functional Imaging Laboratory, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Mumbai 410210, India
*
Author to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 6 March 2017 / Revised: 11 April 2017 / Accepted: 17 April 2017 / Published: 28 April 2017
(This article belongs to the Special Issue Cancer Molecular Imaging in the Era of Precision Medicine)
View Full-Text   |   Download PDF [2911 KB, uploaded 28 April 2017]   |  

Abstract

The unresolved and paramount challenge in bio-imaging and targeted therapy is to clearly define and demarcate the physical margins of tumor tissue. The ability to outline the healthy vital tissues to be carefully navigated with transection while an intraoperative surgery procedure is performed sets up a necessary and under-researched goal. To achieve the aforementioned objectives, there is a need to optimize design considerations in order to not only obtain an effective imaging agent but to also achieve attributes like favorable water solubility, biocompatibility, high molecular brightness, and a tissue specific targeting approach. The emergence of near infra-red fluorescence (NIRF) light for tissue scale imaging owes to the provision of highly specific images of the target organ. The special characteristics of near infra-red window such as minimal auto-fluorescence, low light scattering, and absorption of biomolecules in tissue converge to form an attractive modality for cancer imaging. Imparting molecular fluorescence as an exogenous contrast agent is the most beneficial attribute of NIRF light as a clinical imaging technology. Additionally, many such agents also display therapeutic potentials as photo-thermal agents, thus meeting the dual purpose of imaging and therapy. Here, we primarily discuss molecular imaging and therapeutic potentials of two such classes of materials, i.e., inorganic NIR dyes and metallic gold nanoparticle based materials. View Full-Text
Keywords: NIR fluorescence; molecular imaging; photothermal therapy; gold nanoparticle; cancer NIR fluorescence; molecular imaging; photothermal therapy; gold nanoparticle; cancer
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Vats, M.; Mishra, S.K.; Baghini, M.S.; Chauhan, D.S.; Srivastava, R.; De, A. Near Infrared Fluorescence Imaging in Nano-Therapeutics and Photo-Thermal Evaluation. Int. J. Mol. Sci. 2017, 18, 924.

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