Differential Immune Responses to New World and Old World Mammalian Arenaviruses
AbstractSome New World (NW) and Old World (OW) mammalian arenaviruses are emerging, zoonotic viruses that can cause lethal hemorrhagic fever (HF) infections in humans. While these are closely related RNA viruses, the infected hosts appear to mount different types of immune responses against them. Lassa virus (LASV) infection, for example, results in suppressed immune function in progressive disease stage, whereas patients infected with Junín virus (JUNV) develop overt pro-inflammatory cytokine production. These viruses have also evolved different molecular strategies to evade host immune recognition and activation. This paper summarizes current progress in understanding the differential immune responses to pathogenic arenaviruses and how the information can be exploited toward the development of vaccines against them. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Ly, H. Differential Immune Responses to New World and Old World Mammalian Arenaviruses. Int. J. Mol. Sci. 2017, 18, 1040.
Ly H. Differential Immune Responses to New World and Old World Mammalian Arenaviruses. International Journal of Molecular Sciences. 2017; 18(5):1040.Chicago/Turabian Style
Ly, Hinh. 2017. "Differential Immune Responses to New World and Old World Mammalian Arenaviruses." Int. J. Mol. Sci. 18, no. 5: 1040.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.