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Int. J. Mol. Sci. 2017, 18(5), 1040; doi:10.3390/ijms18051040

Differential Immune Responses to New World and Old World Mammalian Arenaviruses

Department of Veterinary and Biomedical Sciences, University of Minnesota, Twin Cities, 1988 Fitch Ave., Ste 295, Saint Paul, MN 55108, USA
Academic Editor: Susanna K. P. Lau
Received: 31 March 2017 / Revised: 9 May 2017 / Accepted: 9 May 2017 / Published: 12 May 2017
View Full-Text   |   Download PDF [215 KB, uploaded 12 May 2017]

Abstract

Some New World (NW) and Old World (OW) mammalian arenaviruses are emerging, zoonotic viruses that can cause lethal hemorrhagic fever (HF) infections in humans. While these are closely related RNA viruses, the infected hosts appear to mount different types of immune responses against them. Lassa virus (LASV) infection, for example, results in suppressed immune function in progressive disease stage, whereas patients infected with Junín virus (JUNV) develop overt pro-inflammatory cytokine production. These viruses have also evolved different molecular strategies to evade host immune recognition and activation. This paper summarizes current progress in understanding the differential immune responses to pathogenic arenaviruses and how the information can be exploited toward the development of vaccines against them. View Full-Text
Keywords: arenaviruses; Lassa; Junin; hemorrhagic fever; immune evasion; vaccine arenaviruses; Lassa; Junin; hemorrhagic fever; immune evasion; vaccine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ly, H. Differential Immune Responses to New World and Old World Mammalian Arenaviruses. Int. J. Mol. Sci. 2017, 18, 1040.

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