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Int. J. Mol. Sci. 2017, 18(5), 1039; doi:10.3390/ijms18051039

Chronic Kidney Disease and Exposure to Nephrotoxic Metals

Mercer University School of Medicine, Division of Basic Medical Sciences, 1550 College St., Macon, GA 31207, USA
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Academic Editor: Alan Parrish
Received: 7 April 2017 / Revised: 2 May 2017 / Accepted: 5 May 2017 / Published: 12 May 2017
(This article belongs to the Special Issue Advances in Chronic Kidney Disease 2017)
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Abstract

Chronic kidney disease (CKD) is a common progressive disease that is typically characterized by the permanent loss of functional nephrons. As injured nephrons become sclerotic and die, the remaining healthy nephrons undergo numerous structural, molecular, and functional changes in an attempt to compensate for the loss of diseased nephrons. These compensatory changes enable the kidney to maintain fluid and solute homeostasis until approximately 75% of nephrons are lost. As CKD continues to progress, glomerular filtration rate decreases, and remaining nephrons are unable to effectively eliminate metabolic wastes and environmental toxicants from the body. This inability may enhance mortality and/or morbidity of an individual. Environmental toxicants of particular concern are arsenic, cadmium, lead, and mercury. Since these metals are present throughout the environment and exposure to one or more of these metals is unavoidable, it is important that the way in which these metals are handled by target organs in normal and disease states is understood completely. View Full-Text
Keywords: chronic kidney disease; arsenic; cadmium; lead, mercury chronic kidney disease; arsenic; cadmium; lead, mercury
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Orr, S.E.; Bridges, C.C. Chronic Kidney Disease and Exposure to Nephrotoxic Metals. Int. J. Mol. Sci. 2017, 18, 1039.

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