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Int. J. Mol. Sci. 2017, 18(5), 1034; doi:10.3390/ijms18051034

An AAAG-Rich Oligodeoxynucleotide Rescues Mice from Bacterial Septic Peritonitis by Interfering Interferon Regulatory Factor 5

1
Department of Molecular Biology in College of Basic Medical Sciences and Institute of Pediatrics in First Hospital, Jilin University, Changchun 130021, China
2
Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China
3
Department of Endodontics, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, School and Hospital of Stomatology, Jilin University, Changchun 130021, China
4
Department of Respiratory Medicine, The First Hospital of Jilin University, Changchun 130021, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Charles J. Malemud
Received: 9 March 2017 / Revised: 4 May 2017 / Accepted: 6 May 2017 / Published: 11 May 2017
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [3223 KB, uploaded 11 May 2017]   |  

Abstract

A previous study found that an AAAG-rich Oligodeoxynucleotide (ODN), designated as MS19, could lessen the acute lung inflammatory injury (ALII) in mice infected by influenza viruses. Bioinformatics analysis found that MS19 is consensus with the binding site of interferon regulatory factor 5 (IRF5) in the regulatory elements of pro-inflammatory genes. This study established a septic peritonitis model in Institute of Cancer Research (ICR) mice infected with Escherichia coli (E. coli), and found that MS19 prolonged the survival of the mice and down-regulated the expression of inducible nitric oxide synthase (iNOS), interleukin-6 (IL-6), and tumor necrosis factor α (TNF-α). In cultured RAW264.7 cells, MS19 significantly reduced the expression of iNOS, IRF5, IL-6, and TNF-α and inhibited the nuclear translocation of IRF5. This data may provide a new insight for understanding how MS19 reduces the excessive inflammatory responses in sepsis. View Full-Text
Keywords: septic peritonitis; oligodeoxynucleotide; interferon regulatory factor 5; inflammation; macrophage septic peritonitis; oligodeoxynucleotide; interferon regulatory factor 5; inflammation; macrophage
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MDPI and ACS Style

Gao, S.; Li, X.; Nie, S.; Yang, L.; Tu, L.; Dong, B.; Zhao, P.; Wang, Y.; Yu, Y.; Wang, L.; Hua, S. An AAAG-Rich Oligodeoxynucleotide Rescues Mice from Bacterial Septic Peritonitis by Interfering Interferon Regulatory Factor 5. Int. J. Mol. Sci. 2017, 18, 1034.

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