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Int. J. Mol. Sci. 2017, 18(5), 0950; doi:10.3390/ijms18050950

Hypoxia, HIF, and Associated Signaling Networks in Chronic Kidney Disease

1
Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha 410011, China
2
Department of Cellular Biology & Anatomy, Medical College of Georgia at Augusta University and Charlie Norwood VA Medical Center, Augusta, GA 30912, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Alan Parrish
Received: 25 March 2017 / Revised: 21 April 2017 / Accepted: 24 April 2017 / Published: 30 April 2017
(This article belongs to the Special Issue Advances in Chronic Kidney Disease 2017)
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Abstract

The pathogenesis of chronic kidney disease (CKD) is complex and apparently multifactorial. Hypoxia or decrease in oxygen supply in kidney tissues has been implicated in CKD. Hypoxia inducible factors (HIF) are a small family of transcription factors that are mainly responsive to hypoxia and mediate hypoxic response. HIF plays a critical role in renal fibrosis during CKD through the modulation of gene transcription, crosstalk with multiple signaling pathways, epithelial-mesenchymal transition, and epigenetic regulation. Moreover, HIF also contributes to the development of various pathological conditions associated with CKD, such as anemia, inflammation, aberrant angiogenesis, and vascular calcification. Treatments targeting HIF and related signaling pathways for CKD therapy are being developed with promising clinical benefits, especially for anemia. This review presents an updated analysis of hypoxia response, HIF, and their associated signaling network involved in the pathogenesis of CKD. View Full-Text
Keywords: hypoxia; HIF; CKD; fibrosis hypoxia; HIF; CKD; fibrosis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Liu, J.; Wei, Q.; Guo, C.; Dong, G.; Liu, Y.; Tang, C.; Dong, Z. Hypoxia, HIF, and Associated Signaling Networks in Chronic Kidney Disease. Int. J. Mol. Sci. 2017, 18, 0950.

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