Next Article in Journal
Nobiletin Inhibits Angiogenesis by Regulating Src/FAK/STAT3-Mediated Signaling through PXN in ER+ Breast Cancer Cells
Next Article in Special Issue
Chronic Kidney Disease and Exposure to Nephrotoxic Metals
Previous Article in Journal
Antiproliferative and Apoptotic Potential of Cyanidin-Based Anthocyanins on Melanoma Cells
Previous Article in Special Issue
Genetics of Congenital Anomalies of the Kidney and Urinary Tract: The Current State of Play
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2017, 18(5), 0950; doi:10.3390/ijms18050950

Hypoxia, HIF, and Associated Signaling Networks in Chronic Kidney Disease

Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha 410011, China
Department of Cellular Biology & Anatomy, Medical College of Georgia at Augusta University and Charlie Norwood VA Medical Center, Augusta, GA 30912, USA
Author to whom correspondence should be addressed.
Academic Editor: Alan Parrish
Received: 25 March 2017 / Revised: 21 April 2017 / Accepted: 24 April 2017 / Published: 30 April 2017
(This article belongs to the Special Issue Advances in Chronic Kidney Disease 2017)
View Full-Text   |   Download PDF [424 KB, uploaded 3 May 2017]   |  


The pathogenesis of chronic kidney disease (CKD) is complex and apparently multifactorial. Hypoxia or decrease in oxygen supply in kidney tissues has been implicated in CKD. Hypoxia inducible factors (HIF) are a small family of transcription factors that are mainly responsive to hypoxia and mediate hypoxic response. HIF plays a critical role in renal fibrosis during CKD through the modulation of gene transcription, crosstalk with multiple signaling pathways, epithelial-mesenchymal transition, and epigenetic regulation. Moreover, HIF also contributes to the development of various pathological conditions associated with CKD, such as anemia, inflammation, aberrant angiogenesis, and vascular calcification. Treatments targeting HIF and related signaling pathways for CKD therapy are being developed with promising clinical benefits, especially for anemia. This review presents an updated analysis of hypoxia response, HIF, and their associated signaling network involved in the pathogenesis of CKD. View Full-Text
Keywords: hypoxia; HIF; CKD; fibrosis hypoxia; HIF; CKD; fibrosis

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Liu, J.; Wei, Q.; Guo, C.; Dong, G.; Liu, Y.; Tang, C.; Dong, Z. Hypoxia, HIF, and Associated Signaling Networks in Chronic Kidney Disease. Int. J. Mol. Sci. 2017, 18, 0950.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top