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Int. J. Mol. Sci. 2017, 18(4), 895; doi:10.3390/ijms18040895

Acteoside and Isoacteoside Protect Amyloid β Peptide Induced Cytotoxicity, Cognitive Deficit and Neurochemical Disturbances In Vitro and In Vivo

1
National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 11490, Taiwan
2
School of Pharmacy, National Defense Medical Center, Taipei 11490, Taiwan
3
Sinphar Pharmaceutical Co., Ltd., Sinphar Group (Taiwan), Research & Development Center, I-Lan 26944, Taiwan
4
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 40402, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Toshio Morikawa
Received: 1 March 2017 / Revised: 20 April 2017 / Accepted: 20 April 2017 / Published: 24 April 2017
(This article belongs to the Special Issue Biological Activity of Natural Secondary Metabolite Products)
View Full-Text   |   Download PDF [5961 KB, uploaded 24 April 2017]   |  

Abstract

Acteoside and isoacteoside, two phenylethanoid glycosides, coexist in some plants. This study investigates the memory-improving and cytoprotective effects of acteoside and isoacteoside in amyloid β peptide 1-42 (Aβ 1-42)-infused rats and Aβ 1-42-treated SH-SY5Y cells. It further elucidates the role of amyloid cascade and central neuronal function in these effects. Acteoside and isoacteoside ameliorated cognitive deficits, decreased amyloid deposition, and reversed central cholinergic dysfunction that were caused by Aβ 1-42 in rats. Acteoside and isoacteoside further decreased extracellular Aβ 1-40 production and restored the cell viability that was decreased by Aβ 1-42 in SH-SY5Y cells. Acteoside and isoacteoside also promoted Aβ 1-40 degradation and inhibited Aβ 1-42 oligomerization in vitro. However, the memory-improving and cytoprotective effects of isoacteoside exceeded those of acteoside. Isoacteoside promoted exploratory behavior and restored cortical and hippocampal dopamine levels, but acteoside did not. We suggest that acteoside and isoacteoside ameliorated the cognitive dysfunction that was caused by Aβ 1-42 by blocking amyloid deposition via preventing amyloid oligomerization, and reversing central neuronal function via counteracting amyloid cytotoxicity. View Full-Text
Keywords: acteoside; isoacetoside; amyloid β peptide; Morris water maze; acetylcholine; amyloid cascade acteoside; isoacetoside; amyloid β peptide; Morris water maze; acetylcholine; amyloid cascade
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MDPI and ACS Style

Shiao, Y.-J.; Su, M.-H.; Lin, H.-C.; Wu, C.-R. Acteoside and Isoacteoside Protect Amyloid β Peptide Induced Cytotoxicity, Cognitive Deficit and Neurochemical Disturbances In Vitro and In Vivo. Int. J. Mol. Sci. 2017, 18, 895.

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