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Int. J. Mol. Sci. 2017, 18(4), 782; doi:10.3390/ijms18040782

Alleviation of Ultraviolet B-Induced Photodamage by Coffea arabica Extract in Human Skin Fibroblasts and Hairless Mouse Skin

1
Department of Dermatology, China Medical University Hospital, Taichung 40402, Taiwan
2
School of Medicine, China Medical University, Taichung 404, Taiwan
3
Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan
4
Department of Cosmeceutics, China Medical University, Taichung 40402, Taiwan
5
Department of Biotechnology, Asia University, Taichung 41354, Taiwan
6
Department of Sports Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Received: 12 February 2017 / Revised: 22 March 2017 / Accepted: 26 March 2017 / Published: 7 April 2017
(This article belongs to the Section Bioactives and Nutraceuticals)

Abstract

Coffea arabica extract (CAE) containing 48.3 ± 0.4 mg/g of chlorogenic acid and a trace amount of caffeic acid was found to alleviate photoaging activity in human skin fibroblasts. In this study, polyphenol-rich CAE was investigated for its antioxidant and antiinflammatory properties, as well as for its capability to alleviate ultraviolet B (UVB)-induced photodamage in BALB/c hairless mice. The results indicated that 500 μg/mL of CAE exhibited a reducing power of 94.7%, ferrous ion chelating activity of 46.4%, and hydroxyl radical scavenging activity of 20.3%. The CAE dose dependently reduced UVB-induced reactive oxygen species (ROS) generation in fibroblasts. Furthermore, CAE inhibited the UVB-induced expression of cyclooxygenase-2 and p-inhibitor κB, and the translocation of nuclear factor-kappa B (NF-κB) to the nucleus of fibroblasts. In addition, CAE alleviated UVB-induced photoaging and photodamage in BALB/c hairless mice by restoring the collagen content and reduced UVB-induced epidermal hyperplasia. CAE also inhibited UVB-induced NF-κB, interleukin-6, and matrix metalloproteinase-1 expression in the hairless mouse skin. The results indicated that CAE exhibits antiphotodamage activity by inhibiting UV-induced oxidative stress and inflammation. Therefore, CAE is a candidate for use in antioxidant, antiinflammatory, and antiphotodamage products. View Full-Text
Keywords: Coffea arabica; photodamage; antioxidant; inflammatory; nuclear factor-kappa B (NF-κB); inhibitor κB (IκB) Coffea arabica; photodamage; antioxidant; inflammatory; nuclear factor-kappa B (NF-κB); inhibitor κB (IκB)
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MDPI and ACS Style

Wu, P.-Y.; Huang, C.-C.; Chu, Y.; Huang, Y.-H.; Lin, P.; Liu, Y.-H.; Wen, K.-C.; Lin, C.-Y.; Hsu, M.-C.; Chiang, H.-M. Alleviation of Ultraviolet B-Induced Photodamage by Coffea arabica Extract in Human Skin Fibroblasts and Hairless Mouse Skin. Int. J. Mol. Sci. 2017, 18, 782.

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