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Int. J. Mol. Sci. 2017, 18(4), 772; doi:10.3390/ijms18040772

From Lipid Homeostasis to Differentiation: Old and New Functions of the Zinc Cluster Proteins Ecm22, Upc2, Sut1 and Sut2

Division of Biosciences, Brunel University London, Uxbridge UB8 3PH, UK
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Academic Editor: Masatoshi Maki
Received: 28 February 2017 / Revised: 27 March 2017 / Accepted: 31 March 2017 / Published: 5 April 2017
(This article belongs to the Special Issue Metalloproteins 2017)
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Abstract

Zinc cluster proteins are a large family of transcriptional regulators with a wide range of biological functions. The zinc cluster proteins Ecm22, Upc2, Sut1 and Sut2 have initially been identified as regulators of sterol import in the budding yeast Saccharomyces cerevisiae. These proteins also control adaptations to anaerobic growth, sterol biosynthesis as well as filamentation and mating. Orthologs of these zinc cluster proteins have been identified in several species of Candida. Upc2 plays a critical role in antifungal resistance in these important human fungal pathogens. Upc2 is therefore an interesting potential target for novel antifungals. In this review we discuss the functions, mode of actions and regulation of Ecm22, Upc2, Sut1 and Sut2 in budding yeast and Candida. View Full-Text
Keywords: zinc cluster protein; transcription factor; sterol uptake; sterol biosynthesis; anaerobic; filamentation; mating; budding yeast; Candida; antifungal zinc cluster protein; transcription factor; sterol uptake; sterol biosynthesis; anaerobic; filamentation; mating; budding yeast; Candida; antifungal
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Joshua, I.M.; Höfken, T. From Lipid Homeostasis to Differentiation: Old and New Functions of the Zinc Cluster Proteins Ecm22, Upc2, Sut1 and Sut2. Int. J. Mol. Sci. 2017, 18, 772.

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