Next Article in Journal
Characteristic Variations and Similarities in Biochemical, Molecular, and Functional Properties of Glyoxalases across Prokaryotes and Eukaryotes
Next Article in Special Issue
Theranostic Biomarkers for Schizophrenia
Previous Article in Journal
Bevacizumab for Patients with Recurrent Gliomas Presenting with a Gliomatosis Cerebri Growth Pattern
Previous Article in Special Issue
Neuroinflammation and Oxidative Stress in Psychosis and Psychosis Risk
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2017, 18(4), 734; doi:10.3390/ijms18040734

A Novel Bio-Psychosocial-Behavioral Treatment Model in Schizophrenia

1
Department of Psychiatry, Korea University College of Medicine, Seoul 02841, Korea
2
Department of Psychiatry, Hanyang University Guri Hospital, Guri 11923, Korea
3
Department of Psychiatry, Inje University College of Medicine and Haeundae Paik Hospital, Busan 48108, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Johannes Haybaeck
Received: 28 February 2017 / Revised: 25 March 2017 / Accepted: 26 March 2017 / Published: 30 March 2017
View Full-Text   |   Download PDF [212 KB, uploaded 30 March 2017]

Abstract

Despite the substantial burden of illness in schizophrenia, there has been a discrepancy between the beneficial effects of an increased use of antipsychotic medications and achieving limited recovery or remission. Because the focus of the most common antipsychotic medications is on dopamine, which is associated with positive symptoms, there is an unmet need for patients with negative symptoms. Since cognitive and negative symptoms rather than positive symptoms are more closely associated with psychosocial impairments in patients with schizophrenia, the non-dopaminergic systems including glutamate and γ-aminobutyric acid (GABA) of the prefrontal cortex should be of concern as well. The balance of excitation and inhibition has been associated with epigenetic modifications and thus can be analyzed in terms of a neurodevelopmental and neural circuitry perspective. Hence, a novel bio-psychosocial-behavioral model for the treatment of schizophrenia is needed to account for the non-dopaminergic systems involved in schizophrenia, rather than dopaminergic mechanisms. This model can be understood from the viewpoint of neurodevelopment and neural circuitry and should include the staging care, personalized care, preventive care, reducing the cognitive deficits, and reducing stigma. Thomas R. Insel proposed this as a goal for schizophrenia treatment to be achieved by 2030. View Full-Text
Keywords: schizophrenia; bio-psychosocial-behavioral; model; neurodevelopment; neural circuitry; cognitive schizophrenia; bio-psychosocial-behavioral; model; neurodevelopment; neural circuitry; cognitive
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kim, Y.-K.; Choi, J.; Park, S.-C. A Novel Bio-Psychosocial-Behavioral Treatment Model in Schizophrenia. Int. J. Mol. Sci. 2017, 18, 734.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top