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Int. J. Mol. Sci. 2017, 18(4), 709; doi:10.3390/ijms18040709

Recent Advances in Nanoparticle-Mediated Delivery of Anti-Inflammatory Phytocompounds

Institute of Agro-Environmental and Forest Biology (IBAF-CNR), Via Pietro Castellino 111, 80131 Napoli, Italy
Institute for Polymers, Composites, and Biomaterials (IPCB-CNR), Via Campi Flegrei 34, 80078 Pozzuoli (NA), Italy
Department of Chemical Sciences, University of Naples “Federico II”, Via Cynthia 4, 80125 Napoli, Italy
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editors: Paula Andrade and Patrícia Valentão
Received: 1 February 2017 / Revised: 18 March 2017 / Accepted: 23 March 2017 / Published: 28 March 2017
(This article belongs to the Special Issue Natural Anti-Inflammatory Agents)
View Full-Text   |   Download PDF [5593 KB, uploaded 28 March 2017]   |  


Phytocompounds have been used in medicine for decades owing to their potential in anti-inflammatory applications. However, major difficulties in achieving sustained delivery of phyto-based drugs are related to their low solubility and cell penetration, and high instability. To overcome these disadvantages, nanosized delivery technologies are currently in use for sustained and enhanced delivery of phyto-derived bioactive compounds in the pharmaceutical sector. This review focuses on the recent advances in nanocarrier-mediated drug delivery of bioactive molecules of plant origin in the field of anti-inflammatory research. In particular, special attention is paid to the relationship between structure and properties of the nanocarrier and phytodrug release behavior. View Full-Text
Keywords: inflammation; phytochemicals; nanosized delivery systems; polyphenols; carbohydrates; cannabinoids; terpenoids; essential oils; nanoparticles; nanocapsules inflammation; phytochemicals; nanosized delivery systems; polyphenols; carbohydrates; cannabinoids; terpenoids; essential oils; nanoparticles; nanocapsules

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Conte, R.; Marturano, V.; Peluso, G.; Calarco, A.; Cerruti, P. Recent Advances in Nanoparticle-Mediated Delivery of Anti-Inflammatory Phytocompounds. Int. J. Mol. Sci. 2017, 18, 709.

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